Dysphagia in Induced Parkinson's Disease

描述(申请人提供)：帕金森氏症在老年人中发病率较高(Kondziolka等人，1999；Shulz和Grant，2000)。吞咽困难，即异常吞咽，是帕金森病的重要组成部分(Basset，1999；Bushman等人，；Nagaya等人，1998；Logemann，1998；Potulska等人，1999)，影响营养、生活质量，最重要的是影响呼吸道保护。考虑到获取人类功能障碍数据的不可避免的限制，关于帕金森氏病患者吞咽的定量运动学数据有限(例如，Wintzen等人，1994)。来自肌肉的同步肌电数据对正常吞咽至关重要，虽然对于描述运动模式以及最终对吞咽的神经控制至关重要，但几乎不可能从正常人或帕金森病患者身上收集到。在过去的20年里，我们的研究小组在分析动物模型中口腔和咽部功能的运动学和运动模式方面积累了广泛的专业知识，最终目的是更好地了解人类功能障碍。最近化学诱导的猪帕金森氏病模型的发展为我们提供了一个明显的机会，使我们能够将我们的方法和经验应用于与该疾病相关的饲养问题。本研究的目的是在帕金森氏病猪模型中收集初步数据，通过与我们广泛的正常功能对照数据比较，确定吞咽不同阶段的功能障碍程度。我们将使用我们成熟的同步放射成像和肌电成像技术来建立该模型的实用性。我们的最终目标是利用这些数据开发一项旨在系统描述帕金森病患者正常口腔和咽部吞咽功能障碍的R01提案。

DESCRIPTION (provided by applicant): Parkinson's Disease occurs with high incidence in the elderly (Kondziolka et al., 1999; Shulz and Grant, 2000). Dysphagia, abnormal swallowing, is a significant component of Parkinson's disease (Basset, 1999; Bushman et al., 1989; Nagaya et al., 1998; Logemann, 1998; Potulska et al., 1999), impacting on nutrition, quality of life, and most significantly, airway protection. Given the inevitable restrictions on the acquisition of human dysfunction data, there are limited data on the quantitative kinematics of swallowing in patients with Parkinson's Disease (e.g. Wintzen et al., 1994). Synchronous electromyographic data from the muscles critical for normal deglutition, while essential for characterizing the motor patterns, and ultimately the neural control of swallowing, are virtually impossible to collect from either normal or Parkinsonian human subjects. Over the last 20 years, our research group has developed extensive expertise in analyzing the kinematics and motor pattern of oral and pharyngeal function in animal models with the ultimate goal of a better understanding of human dysfunction. The recent development of a chemically induced model of Parkinson's Disease in pigs presents an obvious opportunity for us to bring our methods and experience to bear on the feeding problems associated with this disease entity. The aim of this study is to collect preliminary data, in the pig model of Parkinson's Disease, to establish the extent of dysfunction in the different phases of swallowing by comparing them with our extensive control data on normal function. We will use our proven techniques of synchronized videoradiography and electromyography to establish the utility of this model. Our ultimate goal is to use these data for the development of an R01 proposal aimed at the systematic characterization of the Parkinsonian disruption of normal oral and pharyngeal swallowing function.