FUNCTIONAL OPTICAL MAMMOGRAPHY

描述（由申请方提供）：拟定研究旨在确定采用新开发的技术平台（硬件和软件）的可行性，以基于血管反应和血红蛋白状态的动态测量分析来检测和监测乳腺肿瘤对新辅助化疗的反应。该技术采用非电离光源，并执行快速的体积，多波长的光学测量，从血管反应性和组织氧供应/需求的指标的衍生签名。将通过评价三个具体目标来评估方法的可行性。1)我们会更新软件，进一步提升系统的自动化功能，从而方便收集和分析主要的系统品质控制参数。这将允许确定系统性能和在线反馈其准备情况。2)我们将在可调测量头中引入额外的照明/检测点并优化其位置。指导这些研究的将是含有各种内含物的乳房的3D半球模型的模拟和使用实验室模型的类似研究。3)对于有限数量的健康志愿者和被诊断患有乳腺癌的受试者，我们将量化和表征乳房对各种稳态激发的动态响应。在后一种情况下，这些研究将在新辅助治疗过程中的不同时间重复进行。将使用各种时间序列分析和统计方法分析收集的表面探测器数据和重建的3D图像时间序列，以揭示试验组之间对诱导的稳态激发的显著差异。

DESCRIPTION (provided by applicant): The proposed study seeks to identify the feasibility of adopting a newly developed technology platform (hardware and software) to detect and monitor the response of neoplasms of the breast to neoadjuvant chemotherapy based on analysis of dynamic measures of the vascular response and hemoglobin states. This technology employs nonionizing optical sources and performs rapid volumetric, multi-wavelength optical measures from which are derived signatures of vascular reactivity and indicators of tissue oxygen supply/demand. Methodological feasibility will be assessed by evaluating three specific aims. 1) We will introduce software updates to serve to further automate system capability thereby facilitating the collection and analysis of key system quality control parameters. This will allow determination of system performance and online feedback of its readiness. 2) We will introduce additional illumination/detection sites into the adjustable measuring head and optimize their location. Guiding these studies will be simulation of 3D hemispheric models of the breast containing various inclusions and similar studies using laboratory phantoms. 3) For a limited number of healthy volunteers and subjects diagnosed with breast cancer, we will quantify and characterize the dynamic response of the breast to various homeostatic provocations. In latter case, these studies will be repeated at various times during the course of neoadjuvant therapy. The collected surface detector data and reconstructed 3D image time series will be analyzed using various time series analysis and statistical methods to reveal significant differences among the test groups to the induced homeostatic provocations.