ORGANOCHLORINES AND METALS IN NEW YORK AND THE HUDSON

描述(取自应用程序) 西奈山超级基金基础研究计划是一个协调的， 研究、培训、社区推广和公众的跨学科计划 健康干预。节目？S的目标是预防疾病，发展 有机氯和有机氯相关的功能障碍和环境退化 重金属。该项目中的生物医学研究重点是神经生物学， 内分泌和生殖结果。地理焦点是 哈德逊河下游和纽约市，300公里长，人口稠密， 高度工业化的地区，受到复杂的 有机氯--多氯联苯、滴滴涕、氯丹、狄氏剂和二恶英--以及 重金属，尤其是铅和汞。环保局已宣布哈德逊河下游 全国S最长的超级基金网站。本计划中的研究项目 将研究：1)环境来源、分布和命运 哈德逊河下游和纽约港的有机氯；2)抑制 有机氯对细胞膜外排泵的作用--一种可能的新机制 雌激素作用；3)有机氯对Wnt基因途径的干扰 在女性生殖道中，一种可能的分子遗传机制 发育毒性；4)有机氯暴露与 帕金森病发病过程中的遗传多态；5)累积性 城市食鱼垂钓者对有机氯和重金属的暴露 来自哈德逊河下游和纽约港的贝类； 6)重金属的环境来源、分布和去向；7) 在怀孕和哺乳期间从骨骼中动员储存的铅 神经发育毒性的可能危险因素。该计划包括一个 社区预防/干预研究项目，“预防胎儿 减少当地鱼类消费的神经毒性：一项教育干预 在纽约市的女性中。它包含了生物统计学和 数据管理、暴露评估、稳定铅同位素分析和遗传 分析。外联核心寻求赋予受影响的城市社区以 通过在环境教育方面建立伙伴关系，减少危险废物。多层次的 Trading Core提供一系列环境教育课程 这从高中一直延伸到研究生阶段。行政部门 CORE集成了整个程序的工作，并将 协调我国以预防为中心的公共政策研究 在通信、技术转让和政府联络方面的努力。

DESCRIPTION (Taken from application) The Mount Sinai Superfund Basic Research Program is a coordinated, interdisciplinary program of research, training, community outreach and public health intervention. The program?s goal is to prevent disease, developmental dysfunction and environmental degradation associated with organochlorines and heavy metals. Biomedical studies in the program focus on neurobiological, endocrine and reproductive outcomes. The geographic focus is the watershed of the lower Hudson River and New York City, a 300-km long, densely populated, heavily industrialized region that is contaminated by a complex mix of organochlorines - PCBs, DDT, chlordane, dieldrin, and dioxins - as well as by heavy metals, especially lead and mercury. EPA has declared the lower Hudson River the nation s longest Superfund site. Research projects in this program will examine: 1) environmental sources, distribution and fate of organochlorines in the lower Hudson River and New York Harbor; 2) inhibition of cell membrane efflux pumps by organochlorines, a possible novel mechanism of estrogenic action; 3) disruption by organochlorines of the Wnt gene pathway in the female reproductive tract, a possible molecular genetic mechanism of developmental toxicity; 4) interactions of organochlorine exposures and genetic polymorphisms in the genesis of Parkinson's Disease; 5) cumulative exposures to organochlorines and heavy metals in urban anglers who eat fish and shellfish from the lower Hudson River and New York Harbor; 6) Environmental sources, distribution and fate of heavy metals; 7) mobilization of stored lead from bone during pregnancy and lactation, a possible risk factor for neurodevelopmental toxicity. The program includes a Community-Based Prevention/Intervention Research Project, "Preventing Fetal Neurotoxicity by Reducing Local Fish Consumption: An Education Intervention among Women in New York City." It contains support cores in Biostatistics and Data Management, Exposure Assessment, Stable Lead Isotope Analysis and Genetic Analysis. The Outreach Core seeks to empower urban communities affected by hazardous wastes through partnerships in environmental education. The multi-tiered Training Core offers a range of programs in environmental education that extends from high school through the graduate level. The Administrative Core integrates the work of the entire program and translates the results of research into prevention-centered public policy through coordinating our efforts in communications, technology transfer and government liaison.