The Treatment of Binge Eating Disorder

描述（由申请人提供）：过去几十年的研究 显示超重人群中有一部分人饮食异常， 以不连续的暴饮暴食为特征的模式。的存在 肥胖者的暴饮暴食事件与 精神病理学，社会功能障碍，早发性肥胖，以及更大的 肥胖的严重性。然而，最近的研究表明，暴饮暴食可以 使用某些形式的心理疗法有效治疗肥胖个体 如认知行为技术，以及某些抗抑郁药物， 这些策略也被证明对抑制暴饮暴食有用， 体重正常的神经性贪食症患者 某些自助技术也被证明是非常有用的， 改善暴饮暴食的症状，鼓励健康的饮食行为， 饮食失调的人。我们的研究小组已经证明了 神经性贪食症患者自助手册的实用性 以及最近的一个团体自助方法在瞄准狂欢中的效用 肥胖暴饮暴食者的饮食行为。 因此，作为我们先前研究的延伸，并给出了初步的 将在应用程序中报告的数据，我们建议研究实用程序 针对暴饮暴食的肥胖个体的治疗方法， 一项随机分配、平行研究，其中符合入选标准的受试者 标准将被分配到6个条件之一：1）手动自助 在没有治疗师参与的情况下瞄准暴饮暴食; 2）监督 3）团体自助治疗，不与任何人接触， 心理治疗师; 4）部分通过录像带提供的团体治疗， 部分治疗师领导; 5）传统治疗师领导的小组 心理治疗，以及6）控制时间影响的等待列表控制 以及参与议定书的非特异性影响。值得注意的是， 五个治疗组中的材料基本相同， 而是为自助、视听和治疗介绍而写的， 在治疗分配上。 该方案并非旨在测试减肥策略，而是为了 专注于暴饮暴食的策略这样的战略可以 与各种体重减轻组合或顺序施用 策略（例如，行为学，药理学）的研究。 减肥治疗目前正在经历重大的演变， 在过去的18个月里引进了两种新的药物。我们 我相信，要解决暴饮暴食的问题， 这项研究中的减肥策略将使其过于复杂。的 这项研究的结果可以为治疗这两种疾病的试验设计提供信息。 暴饮暴食，促进减肥。

DESCRIPTION (provided by applicant): Research over the last few decades has shown that a sub-group of overweight individuals have an abnormal eating pattern best characterized by discrete binge eating episodes. The presence of binge eating episodes in obese individuals is associated with increased rates of psychopathology, social dysfunction, early onset obesity, and greater severity of obesity. However, recent research suggests that binge eating can be effectively treated in obese individuals using certain forms of psychotherapy such as cognitive behavioral techniques, and certain antidepressant drugs, strategies that have also been shown to be useful in suppressing binge eating in individuals of normal weight with bulimia nervosa. Certain self-help techniques have also been shown to be quite useful in improving binge eating symptoms and in encouraging healthy eating behavior in individuals with disordered eating. Our research groups have demonstrated the utility of a self-help manual in working with individuals with bulimia nervosa and most recently the utility of a group self-help approach in targeting binge eating behavior in overweight individuals with binge eating. Therefore, as an extension of our prior research, and given the preliminary data that will be reported in the application, we propose to study the utility of treatments targeting binge eating in obese individuals who binge eat through a random assignment, parallel study wherein subjects who satisfy inclusion criteria will be assigned to one of 6 conditions: 1) manual-based self-help targeting binge eating without therapist involvement; 2) supervised manual-based self-help; 3) group self-help therapy, without contact with a psychotherapist; 4) group therapy delivered partially through videotapes and partially with therapist leadership; 5) a traditional therapist-led group psychotherapy, and 6) a wait list control to control for the effects of time and the non-specific effects of being involved in the protocol. Of note, the materials presented in the five treatment arms will be essentially identical, but are written for self-help vs. audio-visual vs. therapy presentation based on the treatment assignment. This protocol is not designed to test a weight loss strategy, but instead to focus on strategies for binge-eating. Such strategies could then be administered in combination with, or sequentially with, various weight loss strategies (e.g., behavioral, pharmacologic) in those who are overweight. Treatments for weight loss are currently undergoing significant evolution with the introduction of two new pharmacologic agents in the last 18 months. We believe that to attempt to address both strategies for binge eating and strategies for weight loss in this study would make it overly complex. The result of this study could inform the design of trials to treat both binge-eating and promote weight loss.