Training in Molecular Basis of Skin Pathobiology

描述(由申请者提供)：俄勒冈健康与科学大学皮肤病学系提出了一项新的培训计划，旨在为皮肤基础和翻译研究方面的学术生涯培养高素质的博士后和博士后。OHSU皮肤科拥有雄厚的临床和科研历史，在皮肤科住院医师培训方面有40年的记录。该计划的特点是：1)皮肤科教授的核心，包括项目主任Kulesz-Martin博士(皮肤癌发生，抑癌基因p53)，以及联合主任王晓静(皮肤癌变的表皮基因开关转基因模型和皮肤疾病中的转化生长因子-β/SMAD通路)，分别拥有24年和14年的皮肤研究和指导经验，Steven Jacques(皮肤光学成像)，Melissa Wong(β-连环蛋白途径，干细胞)，2)一个多学科的科学家团队，在与皮肤细胞生长、分化和凋亡高度相关的领域，包括华录(P63和P53)，Bruce Magun(转化生长因子-β和应激激酶反应)、Peter Rotwein(胰岛素样生长因子/IGF在分化、组织生长和再生中的作用)和Philip Stork(RAS和B-Raf信号在生长和细胞凋亡中的作用)和3)新设计的研究空间总计约6000平方英尺(皮肤科4500平方英尺和俄亥俄州立大学癌症研究所空间1500平方英尺)。三名博士后和两名博士后实习生将从医学博士、博士或医学博士/博士候选人中挑选，他们希望从事皮肤病学研究或具有较强临床翻译成分的基础皮肤研究的学术生涯。标准将包括独立的可能性，推荐信，出版记录，在皮肤科有很大影响的专业知识，以及对服务不足的少数族裔的接触。培训计划包括OHSU的研究生课程、导师系(皮肤科、细胞与发育生物学、生物化学、分子与医学遗传学)的研讨会、每月皮肤科研究部会议和技术研讨会、为博士后或博士后学生量身定做的研究论坛以及皮肤生物学的国内/国际会议。

DESCRIPTION (provided by applicant): The Oregon Health & Science University Department of Dermatology proposes a new training program with objectives to train highly qualified predoctoral and postdoctorals for academic careers in skin basic and translational research. The OHSU Dermatology Department has a strong history of clinical and scientific research and a 40 year record in dermatology resident training. Features of the proposed program are: 1) a core of Dermatology faculty, including program director Dr. Kulesz-Martin (skin carcinogenesis, tumor suppressor p53), and Co-Director Xiao-Jing Wang (epidermal gene-switch transgenic models of skin carcinogenesis and TGF-beta/SMAD pathways in skin disease) with 24 and 14 years experience in skin research and mentorship, respectively, Steven Jacques (cutaneous optical imaging), and Melissa Wong (Beta-catenin pathway, stem cells), 2) a multidisciplinary team of scientists with international recognition in areas highly relevant to skin cellular growth, differentiation and apoptosis, including Hua Lu (p63 and p53), Bruce Magun (TGF-beta and stress kinase responses), Peter Rotwein (insulin-like growth factors/IGFs in differentiation, tissue growth and regeneration) and Philip Stork (Ras and B-Raf signaling in growth and apoptosis) and 3) newly designed research space totaling approximately 6000 sq ft (4500 sq ft in Dermatology and 1500 sq ft of OHSU Cancer Institute space). Three postdoctoral and two pre-doctoral trainees will be selected from M.D., Ph.D. or M.D./PhD candidates who desire an academic career in investigative dermatology or basic skin research with strong clinical translational component. Criteria will include potential for independence, letters of recommendation, publication record, expertise of strong potential for impact in dermatology and outreach to underserved minorities. The training program includes graduate courses at OHSU, seminars in mentors' departments (Dermatology, Cellular & Developmental Biology, Biochemistry, Molecular & Medical Genetics), monthly Dermatology Research Division meetings and techniques seminars, research forums tailored to predoctoral or postdoctoral students and national/international meetings in cutaneous biology.