Nutritional Biochemistry and Epidemiology of Cancer

描述（由申请人提供）：这是1997年最初资助的唯一专注于营养和癌症的培训项目的第一次更新。虽然它得到了相当多的内部支持，并且被认为是癌症研究的一个主要前景，但NCI的外部资金很少集中在营养和癌症领域。营养研究非常引人注目，但也涉及到极其复杂的研究设计，充满了测量误差和潜在偏差，并且由于饮食成分和模式之间的相互关系而变得复杂。需要强有力的培训计划来招募最优秀的科学家进入这一领域，并在发展推进科学和将新技术纳入该领域所需的能力方面提供支持。

DESCRIPTION (provided by applicant): This is the first renewal of the only training program focusing exclusively on nutrition and cancer that was originally funded in 1997. Although it enjoys considerable intramural support, and is recognized as a major promising of cancer research, relatively little of NCI external funding is focused on the area of nutrition and cancer. Nutritional research is very compelling but also involves study designs that are extremely complex, fraught with measurement error, potential biases and is complicated by interrelations among dietary components and patterns. Strong training programs are needed to recruit the best scientists into this area and to provide support in developing the competencies needed to advance the science and incorporate new technologies into the field. We have designed a training program to meet the need of our research community for well-trained and methodologically sophisticated scientists willing to focus their research careers on nutrition and cancer through recruitment of excellent scientists to the field and cross training them in nutritional biochemistry, nutritional epidemiology, and cancer research methods. To prepare fellows for careers in nutritional and cancer research, the program has four specific aims or training objectives. Under the direction of a multidisciplinary Training Advisory Committee and preceptor team, fellows will learn the fundamental biochemistry and epidemiology relevant to nutritional research on carcinogenesis, become competent in research methods central to this field; conduct research in a specific topic area that will further our knowledge of diet and cancer and develop professionally so they can succeed as ethically motivated, productive researchers heading towards academic careers in this field. We are requesting two postdoctoral and six predoctoral trainee positions each year for this purpose.