Training in Environmental Pathology

描述(由申请人提供) 这一跨学科计划的目标是培养一种新的 一代环境病理学家使用细胞的工具 生物学、分子生物学和生物化学研究基本机制 与环境和职业接触有关的疾病。这个 中心焦点是一个独立的实验室研究项目，以探索 生殖或免疫功能改变的发病机制， 神经退行性疾病，或因接触反应性物质而导致的癌症 化学品和氧化剂、内分泌干扰剂、金属、矿物 纤维或压力。博士前实习生将按专业招生 在生物、化学、毒理学或环境科学方面 致力于疾病机制的基础研究。博士后 受训者可以拥有基础科学学科的博士学位， 病理学或毒理学。所有博士前实习生都必须 了解疾病的基本发病机制和形态表现 一门普通病理学课程。培训还提供分子方面的培训。 病理学、成像、遗传毒理学、免疫病理学、环境 毒理学、流行病学和生物统计学、致癌和 分子遗传学。所有受训人员都将接受有关责任的指导 进行研究，并将有机会发展他们的 谢里丹教学中心的沟通和教学技能 和在布朗大学学习。授课课程的补充是 每周研究研讨会，学生期刊俱乐部，职业发展 研讨会和一年一度的环境病理学研讨会。强壮 重点放在沟通技能，勇气， 跨学科的方法和基础研究的影响 监管和公共政策决策。请求继续提供支持 四名博士后和两名博士后实习生。十位教职员工 有积极的、资金充足的研究项目(每年250万美元 直接成本)和使用配备有 激光扫描共聚焦定量成像和形态计量学 显微镜、激光捕获显微切割、质谱学、微阵列 分析、流式细胞术和转基因动物。

DESCRIPTION (provided by applicant) The objective of this interdisciplinary program is to educate a new generation of environmental pathologists to use the tools of cell biology, molecular biology, and biochemistry to study basic mechanisms of disease related to environmental and occupational exposures. The central focus is an independent laboratory research project to explore the pathogenesis of altered reproductive or immune function, neurodegenerative disease, or cancer resulting from exposure to reactive chemicals and oxidants, endocrine disrupting agents, metals, mineral fibers or stress. Pre-doctoral trainees will be recruited with majors in biology, chemistry, toxicology, or environmental sciences and commitment to basic research on mechanisms of disease. Postdoctoral trainees may hold doctoral degrees in a basic science discipline, pathology, or toxicology. All pre-doctoral trainees are required to learn the basic mechanisms and morphologic manifestations of disease in a general pathology course. Training is also provided in molecular pathology, imaging, genetic toxicology, immunopathology, environmental toxicology, epidemiology and biostatistics, carcinogenesis, and molecular genetics. All trainees will be instructed in the responsible conduct of research and will have the opportunity to develop their communication and teaching skills at the Sheridan Center for Teaching and Learning at Brown University. Didactic courses are supplemented by weekly research seminars, student journal clubs, career development workshops, and an annual Environmental Pathology Symposium. Strong emphasis is placed on communication skills, grantsmanship, interdisciplinary approaches, and implications of basic research on regulatory and public policy decisions. Continuing support is requested for four pre-doctoral and two postdoctoral trainees. The ten faculty have active, well-funded research programs ($2.5 million in annual direct costs) and access to modem research facilities equipped for quantitative imaging and morphometry, laser scanning confocal microscopy, laser capture microdissection, mass-spectroscopy, microarray analysis, flow cytometry, and transgenic animals.