Murine Cardiovascular MRI

描述（由申请人提供）： 爱荷华州大学的研究者请求支持购买Varian Unitylnova 4.7 T磁共振成像系统，用于小鼠体内研究。这些研究人员组成了一个欢乐和合议组的研究教师从8个部门在3个学院在爱荷华州大学，从助理教授到部门负责人不等的职级。他们对心血管疾病的机制理解有着持久的热情。这些追求产生的背景和学科范围从综合生理学到分子生物学过渡金属配合物的物理化学。 所要求的仪器的壮观的空间和时间分辨率将用于提供特定生理状态和疾病过程中器官功能的非侵入性定量评估。将在患有梗死后心力衰竭、遗传性扩张型心肌病倾向、左心室压力超负荷、氯离子通道缺陷、败血症和缺血再灌注损伤的小鼠中评估局部心肌收缩功能。大血管的重塑，并将在患有动脉粥样硬化、糖尿病和压力超负荷的小鼠中成像。将在患有糖尿病和动脉粥样硬化的小鼠中对脑梗塞和微血管功能进行成像。将在遗传和饮食诱导的肥胖小鼠模型中研究皮质脂肪分布及其对心血管功能的影响。肿瘤血管生成拟态的革命性概念将在生理学上得到表征。将开发和测试用于心血管结构和功能成像以及用于基因转移的体内成像的新造影剂。 当地在这些技术和生物医学领域拥有大量专门知识。这些项目旨在充分利用所要求的仪器目前已知的能力，而不需要未来的硬件或软件开发。爱荷华州大学已投入大量的财政和行政资源，使用所要求的工具成功和富有成效地追求生物医学知识。

DESCRIPTION (provided by applicant): Investigators from the University of Iowa request support to purchase a Varian Unitylnova 4.7T Magnetic Resonance Imaging System for study of mice in vivo. These investigators comprise a convivial and collegial group of research faculty from 8 departments in 3 colleges within the University of Iowa, ranging in rank from Assistant Professor to Department Head. They share an abiding passion for pursuit of mechanistic understanding of cardiovascular disease. These pursuits arise from backgrounds and disciplines ranging from integrative physiology to molecular biology to the physical chemistry of transition metal complexes. The spectacular spatial and temporal resolution of the requested Instrument will be used to provide non-invasive quantitative assessment of organ function in specific physiological states and disease processes. Regional myocardial systolic function will be assessed in mice with post-infarction heart failure, inherited proneness to dilated cardiomyopathy, left ventricular pressure-overload, chloride channel deficiency, sepsis, and ischemia-reperfusion injury. Remodeling of the great vessels and will be imaged in mice with atherosclerosis, diabetes, and pressure-overload. Cerebral infarction and microvascular function will be imaged in mice with diabetes and atherosclerosis. Corporeal adipose distribution and its consequent effects on cardiovascular function will be studied in genetic and diet-induced mouse models of obesity. The revolutionary concept of tumor vasculogenic mimicry will be physiologically characterized. New contrast agents for imaging cardiovascular structure and function, and for in vivo imaging of gene transfer, will be developed and tested. Significant local expertise in these technical and biomedical fields exists. The Projects are designed to fully utilize the present known capabilities of the requested Instrument, without requiring future hardware or software development. The University of Iowa has committed substantial financial and administrative resources toward successful and productive pursuit of biomedical knowledge using the requested Instrument.