Investigating the relationship between telomere length and cognitive function

端粒长度是细胞衰老的关键决定因素，它与认知功能和脑容量呈正相关。我们的目标是探索在多大程度上共享的环境和遗传因素有助于使用双胞胎模型的这种关系。然后，我们将使用纵向模型和种群遗传方法测试端粒长度是否可以预测9000名老年人与年龄相关的认知衰退，或者与之有因果关系。最后，我们将探讨端粒长度如何影响大脑，通过测试其与海马体特定子场的关联，使用神经成像遗传方法应用tok Biobank数据。

Telomere length, a key determinant of cell ageing, demonstrates positive associations withcognitive function and brain volumes. We aim to explore the extent to which sharedenvironmental and genetic factors contribute to this relationship using twin modelling. Wewill then test if telomere length can predict, or is causally related to, age-related cognitivedecline in 9,000 older adults using longitudinal modelling and population genetic methods.Finally, we will explore how telomere length impacts on the brain by testing its associationwith specific subfields of the hippocampus, using neuroimaging genetic methods applied toUK Biobank data.