Anti-inflammatory effects of Bromelain

描述(由申请人提供)： 研究菠萝酶，一种常用的营养补充剂，在过敏性呼吸道疾病小鼠模型中的抗炎(蛋白酶和免疫调节)作用。 1.确定菠萝酶治疗是否改变了正常幼鼠和OVA诱导的过敏性呼吸道疾病小鼠的肺功能和/或病理生理学。 2.研究菠萝蛋白酶治疗对正常小鼠和卵清蛋白致过敏性呼吸道疾病小鼠肺功能和/或病理生理影响的机制(S)。

DESCRIPTION (provided by applicant): Investigate the anti-inflammatory (protease and immunoregulatory) effects of Bromelain, a commonly used nutritional supplement, in a mouse model of allergic airway disease. 1. Determine if Bromelain treatment alters lung function and/or pathophysiology in normal naive mice and in mice with OVA-induced allergic airway disease. 2. Investigate the mechanism(s) by which Bromelain treatment affects lung function and/or pathophysiology in normal mice and in mice OVA-induced allergic airway disease.