A chemist's approach to solving biological problems

一个工业CASE博士职位（超过4年）可与Vijay Chudasama博士，James Baker博士和LifeArc博士合作，通过创建由位点特异性蛋白质修饰产生的蛋白质缀合物，帮助在这一方向上提供重要步骤。学生将在UCL进行他/她的博士研究，也有机会在LifeArc工作实习。有机化学家显然需要通过化学生物学的管道为生物学领域做出贡献。该项目将基于使用核心合成有机化学来提供实体，以满足形成下一代基于蛋白质的疗法的需求。在位点选择性蛋白质修饰领域，我们正处于开发一种突破性技术的中心，该技术基于将带有反应柄的小分子插入天然二硫键和半胱氨酸。根据我们的经验，在某些肽和蛋白质的修饰中出现了有趣的挑战。有机会为这一领域做出贡献，并对化学生物学领域产生重大影响。学生将在该项目的过程中获得宝贵的研究专业知识，使他们能够胜任未来在学术或工业环境中的就业。该项目将提供合成有机化学和化学生物学以及一系列可转移技能的全面培训。学生也将有很多机会发挥创造力，包括在LifeArc实习

An industrial CASE PhD position (over 4 years) is available to work with Dr Vijay Chudasama, Dr James Baker and LifeArc to aid in providing significant steps in this direction via the creation of protein-conjugates generated by site-specific protein modification. The student will carry out his/her doctoral research at UCL and also have the opportunity for work placements at LifeArc. There is a clear need for Organic Chemists to contribute to the field of Biology through the conduit of Chemical Biology. This project will be based on using core synthetic organic chemistry to deliver entities that will meet the needs of forming the next-generation of protein-based therapeutics. In the area of site-selective protein modification, we are at the centre of developing a ground-breaking technology based on the insertion of small molecules bearing reactive handles into native disulfide bonds and cysteines. With our experience, interesting challenges in the modification of certain peptides and proteins have arisen. There is an opportunity to contribute to this area and make a significant impact to the field of Chemical Biology.The student will gain valuable research expertise during the course of this project, making them well qualified for future employment in either an academic or industrial setting. This project will provide a thorough training in synthetic organic chemistry and chemical biology, as well as in a series of transferable skills. The student will also be given plenty of opportunity to be creative, and includes a placement at LifeArc