Diabetes Research and Training Center

描述（由申请人提供）： 加州大学旧金山分校弗朗西斯科糖尿病中心是加州大学旧金山分校的一个有组织的研究单位，作为糖尿病研究前沿的基础和临床研究企业已经运作了半个多世纪。从历史上看，该计划已经有一个正在进行的丰富计划，试点和可行性研究，强大的基础科学和临床研究接口。该中心的目标是支持直接或间接参与1型和2型糖尿病研究的高度互动的团队，以推进该疾病的研究和治疗。在这项申请中，加州大学旧金山分校糖尿病中心建议建立一个糖尿病研究和培训中心（DRTC），将支持核心实验室，浓缩计划和试点和可行性研究。该中心将包括来自12个部门和有组织的研究单位以及三个UCSF校区的广泛的知识和研究专业知识，专注于基础研究，着眼于临床应用。该中心将联合收割机结合免疫学、代谢研究、细胞生物学和遗传学在糖尿病领域的研究，开发独特的方法来理解和治疗这种毁灭性的疾病。DRTC的研究人员在以下计划领域组织：胰岛细胞生物学，发育生物学，胰岛移植和免疫学，自身免疫，受体和信号传导，肥胖和代谢和肥胖，糖尿病并发症。七个核心设施旨在促进这些科学家的跨学科研究（富集核心，胰岛生产设施核心，显微镜和细胞成像核心，基因组学和生物信息学核心，小鼠遗传学核心，小鼠代谢和人类代谢核心）。试点和可行性补助金计划旨在促进糖尿病研究的新举措，主要是初级教师和糖尿病重点领域以外的高级教师。一个密集的学术充实计划，组织研讨会和各种专题讨论会，旨在使中心研究人员了解最新发现，并保持该中心的研究计划处于生物医学科学的前沿。

DESCRIPTION (provided by applicant): The University of California at San Francisco Diabetes Center, an organized research unit at UCSF, has functioned for more than a half-century as a basic and clinical research enterprise at the forefront of diabetes research. Historically, the program has had an ongoing enrichment program, Pilot & Feasibility studies, strong basic science and clinical research interface. The goal of the Center is to support a highly interactive team involved either directly or indirectly in Type 1 and Type 2 diabetes research to advance the study and treatment of the disease. In this application, the UCSF Diabetes Center proposes to establish a Diabetes Research and Training Center (DRTC) that will support Core Laboratories, an Enrichment Program and Pilot and Feasibility studies. The Center will encompass a broad range of intellectual and research expertise from over 12 departments and organized research units and three UCSF campuses focused on basic research with an eye towards clinical application. The center will combine immunology, metabolic research, cell biology and genetics in the field of diabetes to develop unique approaches to understand and treat this devastating disease. Investigators of the DRTC are organized in the following programmatic areas: Cell Biology of Islets, Developmental Biology, Islet Transplantation and Immunology, Autoimmunity, Receptors and Signaling, and Obesity & Metabolism and Obesity, Complications of Diabetes. Seven Core facilities are designed to facilitate interdisciplinary investigations of these scientists ( Enrichment Core, Islet Production Facility Core, Microscopy & Cellular Imaging Core, Genomics & Bioinformatics Core, Mouse Genetics Core, Mouse Metabolism, and Human Metabolism Cores). A Pilot and Feasibility Grant Program serves to foster new initiatives in diabetes research primarily of junior faculty and those senior faculty from outside the diabetes focus area. An intensive academic enrichment program which organizes seminars and various symposia is designed to keep Center investigators abreast of the latest discoveries and to maintain the research program at this center at the forefront of biomedical science.