CHILD PSYCHIATRY INTERVENTION RESEARCH CENTER

这是纽约州精神病学研究所儿童精神病学干预研究中心（CPIRC）的申请。CPIRC包括：1)中央（行政）核心（主任：David Shaffer，医学博士）将执行所有核心的管理职能，分发小额赠款，监督协议以确保消费者敏感的做法，确保本地NIMH儿科精神药理学研究单位（RUPP）与Ruane早期诊断中心之间的协调，如果资助焦虑症IRC，将维护一个局域网（LAN）来服务所有CPIRC用户；2)临床核心（PI: Rachel Klein博士）将招募和筛选治疗研究的受试者，并提供方案后护理；3)心理治疗核心（PI: Myrna Weissman, Ph.D.）将为手工心理治疗提供培训和档案材料；4)生物统计学、测量、有效性评估核心（PI: Andrew Leon博士）将提供生物统计学和研究设计方面的咨询，为研究人员提供规划和实施有效性研究的建议，为研究人员提供测量选择方面的建议和培训，并管理和定制统一数据库的输入；5)精神药理学核心（PI: Laurence Greenhill， M.D.）将监测安全参数，提供规范精神药理学研究的手册，将提供培训，并将促进与治疗反应相关的药理学和基础科学研究。在过去的四年里，儿童精神病学CRC承担了CPIC将承担的部分（但不是全部）治疗相关职能。CRC筛查了1698名患者，推荐了718名治疗方案，为75个研究项目提供了咨询，为200多份出版物和研究资助申请提供了咨询，并开设了课程，总人数达数百人。CRC用户是富有成效的：在4年的时间里，撰写了367篇与中心活动相关的出版物。这种繁荣的研究环境将由中国保监会维护。ccirc将拥有大量经验丰富的研究人员和28个资助的治疗方案。它将为成功招聘提供必要的基础设施，在广泛使用价值未经证实的医疗和心理疗法以及对儿童和青少年安全的领域提供急需的精密设计。

This is an application for a Child Psychiatry Intervention Research Center (CPIRC) at New York State Psychiatric Institute. The CPIRC comprises: 1) The Central (Administrative) Core (Director: David Shaffer, M.D.) will perform administrative functions for all Cores, distribute small grants, oversee protocols to insure consumer-sensitive practice, insure coordination between the locally based NIMH Research Unit for Pediatric Psychopharmacology (RUPP), the Ruane Early-Diagnosis Center, and if funded the Anxiety Disorders IRC, will maintain a local Area Network (LAN) to serve all CPIRC users; 2) a Clinical Core (PI: Rachel Klein, Ph.D.) will recruit and screen subjects for treatment studies and will provide post-protocol care; 3) a Psycho-therapy Core (PI: Myrna Weissman, Ph.D.) will provide training and archival materials for manualized psychotherapies; 4) a Biostatistics, Measurement, Effectiveness Evaluation Core (PI: Andrew Leon, Ph.D.) will provide consultation on biostatistics, and research design, that will advise investigators on planning and conducting of effectiveness studies that will advise and train research staff on measurement choice and will manage and customize entry into a uniform database; and 5) a Psychopharmacology Core (PI: Laurence Greenhill, M.D.) that will monitor safety parameters, provide manuals to standardize psychopharmacology studies, will provide training and will facilitate pharmacological and basic science studies related to treatment response. Over the past four years, there has been a Child Psychiatry CRC that performed some but not all the treatment related functions that will be carried out by the CPIC that CRC screened over 1,698 individuals and referred over 718 to treatment protocols, provided consultation on 75 research projects, provided over 200 consultations related to publications and research-grant applications, and given courses whose combined audiences numbered in the hundreds. CRC users were productive: over a 4 year period wrote 367 publications that related to Center activities. This flourishing research environment, will be maintained by the CPIRC. The CPIRC will start life with a large number of experienced researchers and 28 funded treatment protocols. It will provide the infrastructure necessary for successful recruitment, sophisticated design badly needed in a field characterized by the widespread use of medical and psychotherapies of unproven value and safety for children and teens.