CORE GRANT FOR VISION RESEARCH

本申请是为了续期NEI核心资助，以支持12名首席研究员的研究项目，他们持有14项有效的NEI个人研究资助（R01和K23）和NEI机构培训资助。这些研究人员组成了视觉科学研究中心（VSRC）的核心，这是一个由30名视觉研究人员组成的更广泛的小组，他们来自大学医院研究所（UHRI）、凯斯西储大学医学院（CWRU）和克利夫兰退伍军人医疗中心的13个不同的基础和临床科学部门。我们的研究人员利用从分子到行为水平的一系列技术来研究视觉研究中的一系列问题。我们的第一笔核心拨款，以及UHRI和CWRU的大量机构支持，已经允许创建和成功使用三个模块：组织培养和细胞分析，分子生物学和专业动物资源。在这个应用程序中，每个模块的活动都经过了改进，以便根据Pis需求的变化，最有效、最公平地使用共享资源。为了利用快速变化的技术，我们还建议创建两个新模块，一个是数字成像模块，以满足对专业图像捕获功能的专业知识日益增长的需求，另一个是生物信息学模块，将为DNA测序和全基因组筛选数据的高级分析提供共享服务，以及生物信息学方面的重要培训。我们的分子也将作为CWRU新的视觉科学培训计划的前和博士后培训生的整体资源。有了对这一更新的坚定承诺，额外的47.5万美元的机构支持，以及在加强个人项目的同时追求共同目标的热情，VSRC的研究人员期待着继续努力，分析眼睛和视觉系统发育、功能和眼睛和视觉系统疾病的发病机制的基本机制。

This application is for the renewal of an NEI Core Grant in support of the research programs of 12 Principal Investigators holding 14 active NEI individual research grants (R01 and K23) and an NEI Institutional Training Grant. These investigators form the nucleus of the Visual Sciences Research Center (VSRC), a broader group of 30 vision researchers in 13 different basic and clinical science departments at the University Hospital Research Institute (UHRI), Case Western Reserve University School of Medicine (CWRU), and the Cleveland VA Medical Center. Our investigators utilize a range of techniques, from molecular to behavioral levels, to study a spectrum of problems in vision research. Our first Core Grant, and substantial institutional support from UHRI and CWRU, has allowed the creation and successful use of three modules: Tissue Culture and Cell Analysis, Molecular Biology, and Specialized Animal Resource. In this application the activities of each module have been refined to provide the most efficient and equitable use of shared resources as the needs of our Pis change. To capitalize on rapidly changing technologies, we also proposed the creation of two new modules, a Digital Imaging Module to meet a growing need for expertise in specialized image capture functions, and a Bioinformatics Module which will provide shared services for DNA sequencing and advanced analysis of genome-wide screening data, along with vital training in bioinformatics. Our molecules also will serve as an integral resource for pre- and postdoctoral trainees in the new CWRU Visual Sciences Training Program. With a strong commitment toward this renewal, an additional $475,000 of institutional support, and an enthusiasm to pursue common goals and objectives while enhancing individual programs, the VSRC investigators look forward to continuing efforts towards analysis of fundamental mechanisms in ocular and visual system development, function, and pathogenesis of diseases of the eye and visual system.