Core--Tissue Procurement

组织采购核心旨在促进基于人类标本的癌症研究。CORE在前瞻性研究设计的各个方面协助西特曼癌症中心(SCC)的研究人员，从制定适当的知情同意文件到样本收集、存储和处理的协议。Core还保存了数千个代表常见和罕见肿瘤类型的快速冷冻组织样本的档案。经批准的研究人员可以立即获取这些标本进行回顾性翻译研究。重点是向研究人员提供质量受控的组织切片或纯化的大分子(RNA、基因组DNA、蛋白质提取物)，以便立即用于组织学、遗传学或生化研究。此外，核心还提供SCC成员 获得基于组织的研究的新技术，如激光捕获组织显微切割(LCM)和组织微阵列(TMA)构建。到目前为止，该中心已经帮助来自多个研究项目(包括基础科学和临床研究)的几个SCC资助成员收集和利用人类肿瘤组织样本。

The Tissue Procurement Core is designed to facilitate human specimen-based cancer research. The Core assists Siteman Cancer Center (SCC) investigators in all aspects of prospective study design, from the development of appropriate informed consent documents to protocols for specimen collection, storage and processing. The Core also maintains an archive of several thousand snap frozen tissue specimens representing both common and rare tumor types. Approved investigators may immediately access these specimens for retrospective translational studies. Emphasis is placed on delivering quality-controlled histological sections or purified macromolecules (RNA, genomic DNA, protein extracts) to the investigator for immediate use in histological, genetic or biochemical studies. In addition, the Core provides SCC members access to new technologies for tissue-based research, such as Laser Capture Tissue Microdissection (LCM) and Tissue Microarray (TMA) construction. To date, the Core has assisted several funded SCC members from multiple research programs (both basic science and clinical investigation) in the collection and utilization of human tumor tissue specimens.