CORE--Environmental Epidemiology Research Core

描述(由申请人提供)：环境流行病学研究核心(EERC) 任务是促进在EHS中心进行与以下方面有关的多学科研究 环境暴露以及这些因素与影响人类健康和生活质量的生活方式特征、人类生物机制和系统以及遗传易感性之间的相互关系。核心的重点是三个疾病领域：过敏和哮喘、癌症和神经疾病。底特律大都市区是一个特别丰富的人口实验室，可以在其中进行这样的研究，因为它在种族和文化、社会经济地位、职业和环境特征方面极其多样化。这个地点还增强了S中心的研究能力，包括使用自动化数据库识别定义明确和具有特色的研究人群的能力(例如，亨利·福特医疗系统拥有的健康联盟计划的成员和全国第十大HMO；亨利·福特医疗集团服务的人口，约占底特律地区25%；24,600名老年人参加底特律地区的前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验)，以及存在美国国家癌症研究所指定的全国最古老的SEER癌症登记机构之一，该登记机构一直是非裔美国人癌症数据的主要贡献者。核心使命是通过提供机会来整合核心成员的专业知识和想法，以及通过成员与其他EHS中心研究和设施核心调查人员的互动来实现的。核心的目标是：1)推进 在EHS中心开展多学科和跨机构的流行病学研究，在与环境和职业毒理学及特应性疾病、癌症和神经疾病相关的特定内容领域进行研究；2)利用EHS中心的核心专业知识，在环境流行病学研究中促进暴露、易感性和疾病的最新生物标记物的测量；3)培养核心成员与其他EHS中心成员，包括社区外联和教育计划和EHS设施核心，以及与其他EHS中心和NIEHS的研究人员的正式和非正式互动。

Description (provided by applicant): The Environmental Epidemiology Research Core's (EERC) mission is to foster the conduct of multi-disciplinary research in the EHS Center relating to environmental exposures and how such factors interrelate to lifestyle characteristics, human biological mechanisms and systems, and genetic susceptibility to affect human health and quality of life. The focus in the Core is in three disease areas: allergy and asthma, cancer, and neurological diseases. The Detroit metropolitan area is an exceptionally rich population laboratory in which to conduct such research as it is extraordinarily diverse in terms of ethnicity and culture, socioeconomic status, occupations, and environmental characteristics. Other features of this location that augment the Center?s research capacity include the ability to identify, using automated data bases, well defined and characterized study populations (e.g. members of the Health Alliance Plan, owned by Henry Ford Health System and the tenth largest HMO in the country; the population served by the Henry Ford Medical Group, approximately 25% of the Detroit area; 24,600 older individuals enrolled in the Detroit area Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial), and the presence of one of the oldest NCI designated SEER cancer registries in the nation, which has been the predominant contributor of cancer data on African Americans. The Core mission is realized both by opportunities provided to coalesce the expertise and ideas of Core members, and by members' interactions with the other EHS Center Research and Facility Core investigators. Goals of the Core are to: 1) advance the performance of multi-disciplinary and inter-institutional epidemiological research in the EHS Center, in content specific areas relevant to environmental and occupational toxicology and atopic diseases, cancer and neurological diseases; 2) foster state-of-the-art measurement of biological markers of exposure, susceptibility and disease within environmental epidemiology studies, using EHS Center core expertise; 3) Cultivate formal and informal interactions of Core members with other EHS Center members, including the Community Outreach and Education Program and EHS Facility Cores, and externally with investigators at other EHS Centers, and at NIEHS.