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Role of the IgE-FceRI network in allergic inflammation

Role of the IgE-FceRI network in allergic inflammation
IgE-FceRI 网络在过敏性炎症中的作用
批准号：
6892884
负责人：
JEAN-PIERRE M KINET
金额：
$38.25万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
项目状态：
已结题
起止时间：
2001-09-30 至 2006-05-31
来源：
https://reporter.nih.gov/project-details/6892884
关键词：
anaphylaxisanimal breedingantibody receptorantigen presentationasthmaeosinophilgenetically modified animalshypersensitivityimmunoglobulin Elaboratory mousemacrophagemonocytepassive immunizationreceptor expression

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中文摘要
翻译
该提案概述了一个旨在满足哮喘和过敏性疾病研究(AADRC)要求的项目。IgE-FceRi网络在变态反应性炎症中的作用所有人都被三个主要步骤导致哮喘疾病的发展这一中心主题联系在一起：针对过敏原的初始免疫阶段(步骤1)，Th2反应的放大(步骤2)，以及效应器反应和哮喘的发展(步骤3)。该项目的假设是，以Alphagamma2形式表达高亲和力IgE受体的细胞有助于调节IgE免疫反应(步骤2)，并参与体内IgE-FcepsilonRI网络的效应功能(步骤3)。
英文摘要
This proposal outlines a project designed to meet the requirements for an Asthma and Allergic Diseases Research (AADRC). Role of the IgE-FceRi network in allergic inflammation. All are united by the central theme that three major steps lead to the development of the asthmatic disease: the initial immunization phase against allergens (step 1) the amplification of the Th2 response (step 2), and the development of the effector response and asthma (step3). The hypothesis of this project is that cells expressing high affinity IgE receptor in the form of alphagamma2 contributes to the regulation of the IgE immune response (step 2) and participates in the effector functions of the IgE- FcepsilonRI network in vivo (step 3).
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