OptoAcoustic and Ultrasonic Imaging of Angiogenesis

描述（由申请人提供）： 这项“血管生成的光声和超声成像”的提案首次将光声和超声结合在一台仪器中。配备有光纤用于输送激光照明的12 MHz相控阵超声探头将在向后模式下操作。在该方法中，超声图像和光声图像将在空间上重叠，然后在某些表示中融合。超声图像将包括B模式、彩色血流多普勒、能量多普勒和频谱多普勒。叠层换能器将接收时的声谱能力加倍至24 MHz，以实现新生血管化中非常小的血管的可视化。 OPO激光器将从红外波长的光谱中提供窄波长的光，以在光度上选择不同的化合物用于光吸收、扩展和超声波发射。小血管区域中氧合/脱氧血红蛋白的估计值将显示为图像叠加。 这种独特的仪器在光声学中区分血液，在超声中区分组织，允许非常高的血管分辨率，它们的流量（特别是不干扰壁运动的低流量）和它们的氧含量。 WinProbe的科学研究平台将针对这种新的模式组合进行优化，并将在真实的时间内生成融合图像。 该提案包括临床研究，以成像和定量访问已知抗血管生成药物作用下的小鼠血管生成。其目标是将一种用于临床研究的仪器商业化。 血管生成在癌症中的作用在文献中有很好的记载，并且可以预期该仪器将对癌症研究的科学做出重大贡献。 预计未来的商业产品将用于内窥镜仪器，以帮助检测光学评估仅限于表面且缺乏对比度的癌症。

DESCRIPTION (provided by applicant): This proposal for "Optoacoustic and Ultrasonic Imaging of Angiogenesis" combines optoacoustics and ultrasound in a single instrument for the first time. A I 2MHz phased array ultrasound probe equipped with fiber optics for delivery of laser illuminations will operate in the backwards mode. In this method the ultrasonic image and the optoacoustic image will be spatially overlaid and then fused in some presentations. The ultrasonic images will include B-Mode, color Flow Doppler, power Doppler and Spectral Doppler. A stacked transducer will double the acoustic spectral capabilities to 24 MHz on reception to attain visualization of very small vessels in the neovascuIarization. An OPO laser will provide a narrow wavelength from a spectrum of Infra Red wavelengths of light to photometrically select different compounds for light absorption, expansion and emission of ultrasound. Estimation of the oxy / deoxy hemoglobin in small vascular regions will be displayed as an image overlay. This unique instrument differentiates blood in optoacoustics, and tissue in ultrasound, allowing very high resolution of blood vessels, their flow (especially low flow without interference of wall motion) and their oxygen content. WinProbe's Scientific Research Platform will be optimized for this new combination of modalities and will produce fused images in real time. This proposal includes clinical studies to image and quantitatively access angiogenesis in mice under the effect of known anti-angiogenesis drugs. The goal is to commercialize an instrument for clinical research. The role of angiogenesis in cancer is well documented in the literature and this instrument can be expected to make a significant contribution to the science of cancer research. Future commercial products are expected to follow in endoscopic instruments to assist in the detection of cancer where optical assessments are limited to the surface and are contrast deprived.