Developmental Pathways of Adolescent Drug Abuse

该独立科学家奖（K 02）旨在帮助申请人获得必要的技能，以加强青少年吸毒行为（包括物质使用障碍（SUD））发展途径的工作，特别关注长期途径。K 02提供的密集学习期将允许申请人通过课程，研讨会和与该领域专家的咨询获得科学技能。具体而言，职业发展计划将加强对现有数据的分析，并加强对现有预期样本的未来研究，重点是在以下方面打下坚实的基础：（a）先进的统计建模技术和相关的方法问题;（B）与青少年（从十几岁到二十几岁的发展时期）有关的理论基础和相关模型;及（c）创新的短暂干预策略，作为预防青少年从药物使用失调症康复中复发的策略，所发挥的作用。 增强的统计技能将应用于明尼苏达大学的预期纵向数据集以及其他国家数据集。当地的数据代表两个青年群体：一个风险群体和一个物质使用障碍（SUD）群体。高危人群包括在儿童时期被诊断患有ADHD，行为障碍（CD）/对立违抗性障碍（ODD）或两者兼而有之的青少年。这些青少年中的一些人在青春期发展了SUD，而另一些人则有发展迟发性SUD的风险。第二个数据集，SUD组，由青少年组成，他们在青少年时被诊断为SUD并接受治疗，ADHD和CD/ODD是常见的合并症。后一组是相关的SUD的过程中的研究，作为青年年龄对青年成年。两个样本都有年龄、性别、种族和SES匹配的正常组，用于比较分析。基于迄今为止的实证研究结果，具体的假设集中在外部化障碍（如ADHD和CD/ODD）作为可能的预测因子，后果，或青少年吸毒行为的发展途径的调节剂。在假设检验中也将考虑选择的个人（心理困扰）和环境（同龄人的药物使用，父母的做法和治疗经验）因素。 该奖项的目的是通过澄清破坏性行为的作用来推进对青少年物质使用障碍的原因和后果的研究，该奖项将有助于提高研究者在研究青少年长期过程中的技能，这些青少年要么有发展SUD的风险，要么经历了一个短暂发作的SUD。

DESCRIPTION (provided by applicant): This independent scientist award (K02) is proposed for the applicant to acquire necessary skills for enhancing work on the developmental pathways of adolescent drug use behaviors including substance use disorders (SUD), with a particular focus on long-term pathways. The intensive period of study afforded by a K02 will permit the applicant to gain scientific skills via coursework, workshops and consultations with experts in the field. Specifically, the career development plan will enhance the analysis of current data and the development of future studies of existing prospective samples by focusing on the acquisition of a thorough foundation in (a) advanced statistical modeling techniques and related methodological issues; (b) the theoretical underpinnings and relevant models associated with young adulthood, the development period from the late teens through the twenties; and (c) the role of innovative brief intervention strategies as relapse prevention strategies for youth who are recovering from a prior substance use disorder. The enhanced statistical skills will be applied to prospective longitudinal data sets at the University of Minnesota, as well as other national data sets. The local data represent two youth groups: an at-risk group and a substance use disorder (SUD) group. The at-risk group consists of teenagers who were diagnosed with ADHD, Conduct Disorder (CD)/Oppositional Defiant Disorder (ODD) or both during childhood. Some of these youth have either developed an SUD during adolescence whereas others are at-risk for developing a later-onset SUD. The second data set, the SUD group, consists of adolescents who were diagnosed with and treated for a SUD as a teenager and for whom ADHD and CD/ODD are common comorbidities. This latter group is relevant to the study of the course of SUD as the youth age toward young adulthood. Both samples have normal groups matched on age, gender, race, and SES fo use in comparative analyses. Based on empirical findings to date, the specific hypotheses focus on externalizing disorders (e.g. ADHD and CD/ODD) as possible predictors, consequences, or moderators of the developmental pathways of adolescent drug use behaviors. Select personal (psychological distress) and environmental (drug use by peers, parenting practices, and treatment experiences) factors will be considered in hypothesis testing as well. The aims of this award will advance research on the cause and consequences of adolescent substance use disorders by clarifying the role of disruptive behaviors, and the award will help enhance the investigator's skills in researching the long-term course of adolescents who are either at-risk for developing an SUD or have experienced an adolescent-onset SUD.