qEP Analysis of Comatose Patients: Mutal Synchronicity

描述(由申请人提供)：据估计，美国每年约有250,000-300,000人经历心肺骤停(CPA)。大约80%的复苏患者仍处于昏迷状态一段时间。尽管现代医疗保健努力，但这些患者中的许多人不会醒来。 在这种情况下，照顾者面临着继续积极治疗或停止生命支持的艰难选择。在评估这些昏迷患者的整体临床情况时，诱发电位(EP)可以为脑功能提供有用的辅助反馈。因此，我们提出了一项第一阶段的努力，以开发定量EP(QEP)分析技术来评估昏迷患者。具体地说，我们提出了相互同步性(MS)作为一种方法，将幅度和潜伏期分析的各个方面结合到脑损伤的统一测量中。 我们第一阶段研究的目标是1)基于先进的信号处理理论开发相互同步性(MS)，以客观地表征皮质和脑干的电活动，以及2)在CPA后恢复期间对昏迷患者进行MS测试。从长远来看，我们计划调查这项技术作为监测CPA后昏迷进展的床边工具的使用。

DESCRIPTION (provided by applicant): It is estimated that approximately 250,000-300,000 people experience cardiopulmonary arrest (CPA) each year in the United States. Approximately 80% of resuscitated patients remain in a coma for some time. Despite modern day healthcare efforts, many of these patients will not awaken. In such cases, caregivers are confronted with the difficult choice of continuing aggressive therapy or withdrawing life support. In evaluating the overall clinical picture of these comatose patients, Evoked Potentials (EP) may provide useful adjunct feedback on brain function. Thus we propose a Phase I effort to develop quantitative EP (qEP) analysis techniques for evaluation of comatose patients. Specifically, we propose Mutual Synchronicity (MS) as a method to combine aspects of amplitude and latency analysis into a unifying measure of brain injury. The goals of our Phase I study are 1) to develop Mutual Synchronicity (MS) based on advanced signal processing theory for objectively characterizing cortical and brainstem electrical activity, and 2) to test MS in a preliminary evaluation of comatose patients during post-CPA recovery. In the long-term, we plan to investigate the use of this technology as a bedside tool for monitoring the progression of coma after CPA.