X-ray Phase Imaging Tomography System for Small Animals

描述（由申请人提供）： 该项目的主要目的是开发一种新型的X射线成像系统，用于对小动物进行体内成像。该系统将提供20 μ m和2 μ m两种分辨率模式，利用相位成像的新概念，从而减少曝光时间和辐射剂量。与当前商业成像系统中使用的吸收对比度相比，相位对比度将对用于研究癌症、血管生成和表型的软组织成像高度敏感。除了2D相位成像能力外，它还能够对麻醉动物进行3D定量相位断层扫描。20um分辨率模式具有20mm的视场，而2um模式具有2mm的视场。这两种分辨率模式提供了目前尚不具备的灵活性。

DESCRIPTION (provided by applicant): The primary aim of this project is to develop a novel x-ray imaging system for imaging small animals in-vivo. This system will provide two resolution modes at 20um and 2um utilizing a novel concept for phase imaging which results in reduced exposure time and radiation dose. In comparison with absorption contrast used in current commercial imaging systems, the phase contrast will be highly sensitive to imaging soft tissues for studying cancer, angiogensis and phenotyping. In addition to its 2D phase imaging capability it will be capable of performing 3D quantitative phase tomography on an anesthetized animal. The 20um resolution mode has a field of view of 20mm while the 2um mode has a field of view of 2mm. The two resolution modes offer flexibility that is not currently available.