Scientific & Clinical Symposium on Tourette Syndrome

描述（由申请人提供）：抽动秽语综合征（TS）是一种以运动和声音抽搐为特征的神经行为障碍。抽搐始于儿童时期，随着时间的推移，其严重程度会有所减弱。TS可能与相当大的痛苦以及社交、学业和职业障碍有关。一度被认为罕见的TS，目前的患病率估计为0.8%。TS的确切病因尚不清楚，遗传和环境因素都与其病因有关。在过去的四年里，随着临床护理的重要进展，对TS的研究急剧增加。第四届图雷特综合征国际科学与临床研讨会将于2004年6月25日至27日在克利夫兰诊所基金会举行。值得注意的是，抽动秽语综合症协会（TSA）与NIMH和NINDS共同主办了三次关于抽动秽语综合症的国际科学和临床专题讨论会。第一次是在1981年，随后是十年后的1991年和1999年。这些专题讨论会已成为更新基础和临床研究人员当前研究成果的中心论坛。本次研讨会还将为未来的TS研究工作和临床护理制定议程。2004年召开第四届研讨会，既及时又重要。自1999年上次研讨会以来，我们看到了TS科学出版物、TS研究资金以及该疾病临床管理方面的进展的大幅增加。新的科学发现与TS的生物学基础以及临床护理的新方法和改进方法相关。赞助组织，美国运输安全管理局，为TS研究的快速发展做出了巨大贡献，重要的是，它的传播。运输安全管理局有一个非常成功的研究奖励计划。自1984年以来，运输安全管理局资助了252名调查人员，总金额为830万美元。许多新的研究成果将在提议的研讨会上展示，这些成果直接来自过去或现在的tsa资助，以及遗传学、神经影像学、临床试验和行为科学方面的大型合作研究联盟的积极促进。运输安全管理局在传播研究成果方面有一个广泛的议程。第四届国际科学和临床研讨会是一项计划工作的一部分，目的是确定当前的研究进展，在科学界传播这些进展，并建立基础和临床科学家网络。

DESCRIPTION (provided by applicant): Tourette Syndrome (TS) is a neurobehavioral disorder characterized by motor and vocal tics. Tics begin in childhood, and wax and wane in severity over time. TS can be associated with considerable distress, and social, academic and vocational impairment. Once considered rare, the prevalence of TS is currently estimated to be 0.8%. The exact cause of TS is unknown with both genetic and environmental factors implicated in its etiology. Research in TS has increased dramatically over the past four years, as have important advances in clinical care. Funding is requested for partial support of the 4th International Scientific & Clinical Symposium on Tourette Syndrome to be held June 25-27, 2004 at the Cleveland Clinic Foundation. It should be noted that the Tourette Syndrome Association (TSA) co-sponsored with the NIMH and NINDS the three previous International Scientific and Clinical Symposia on Tourette Syndrome. The first was in 1981, followed a decade later in 1991 and again in 1999. These symposia have served as the central forum for updating basic and clinical researchers in current research findings. This symposium will also set the agenda for future TS research efforts and clinical care. Convening the 4th Symposium in 2004 is both timely and important. Since the last symposium in 1999 we have seen a substantial increase in TS scientific publications, TS research funding, as well as advances in clinical management of this disorder. The new scientific findings are relevant to both the biological underpinnings of TS as well as to new and refined approaches to clinical care. The sponsoring organization, the TSA, has contributed greatly to the rapid advances in TS research and importantly, its dissemination. TSA has a very successful research award program. Since 1984 the TSA has funded 252 investigators for a total 8.3 million dollars. Many of the new research findings to be presented at the proposed Symposium result directly from past or current TSA-funding and active facilitation of large collaborative research consortia in genetics, neuroimaging, clinical trials and the behavioral sciences. The TSA has a broad agenda for the dissemination of research findings. The 4th International Scientific and Clinical Symposium is part of a planned effort to identify current research advances, disseminate them within the scientific community, and establish networks of basic and clinical scientists.