Conference--Pathogenesis of Neuroimmunologic Disease

描述（由申请人提供）：本申请代表以下请求： 继续支持举办题为“艾滋病毒/艾滋病发病机制”的短期课程， 伍兹海洋生物实验室提供的“神经免疫疾病” 马萨诸塞州霍尔预计该课程将每两年开设一次 2001年、2003年和2005年。该课程提供了一个全面的调查， 一系列神经系统疾病的发病机制， 精神疾病，包括一个学院，人数约40人，由 具有广泛专业知识的基础科学家和医学科学家。的 两周的讲座计划将描述遗传， 目前使用的分子和细胞生理学概念和技术， 免疫学和神经生理学的方法来分析 被认为具有免疫基础的更为人所知的神经系统疾病。 免疫病理机制讲座将涉及：神经抗原和 与神经和免疫系统的细胞成分，它们的遗传 控制，以及它们的相互作用;与抗原加工和呈递， 免疫发生和耐受发生;细胞因子，补体，神经内分泌， 和“心理神经免疫学”的关系;以及病毒在 神经系统的免疫病理学紊乱。免疫原性抗体介导的 “自身免疫性”疾病包括：重症肌无力，格林巴利病， 和副肿瘤性疾病原代细胞介导的“自身免疫”疾病 将包括：急性感染后脑脊髓炎，多发性硬化症， 眼睛、自主神经系统的慢性炎性疾病，以及 肌肉.额外的讲座将处理持续的病毒感染的 神经系统和慢性炎症性疾病的中枢神经系统有关的免疫 功能障碍，如：HTLV- 1相关的脊髓病，进行性多灶性 白质脑病、SSPE、艾滋病的神经系统表现，以及 老年痴呆症这些演讲将涉及潜在的机制 疾病过程和损伤形成，以及它们的生理后果。 这些会议将补充示范的病人与典型的 神经免疫性疾病和相关的病毒和 动物的自身免疫模型。

DESCRIPTION (provided by applicant): This application represents a request for continued support for a short course entitled "Pathogenesis of Neuroimmuno1ogical Diseases" offered at the Marine Biological Laboratory, Woods Hole, MA. It is anticipated that the course will be offered every other year for 2001, 2003 and 2005. The course offers a comprehensive survey of current concepts in the pathogenetic mechanisms involved in a series of neurologic and psychiatric diseases, and includes a faculty, numbering about 40, composed of basic scientists and physician scientists with a wide area of expertise. The two week program of lectures will describe the application of genetic, molecular, and cell physiologic concepts and techniques in current use in immunology and neurophysiology to the analysis of the pathogenesis of the better known neurologic diseases thought to have an immune basis. Lectures in Immunopathologic Mechanisms will deal with: neural antigens and with the cellular components of the nervous and immune systems, their genetic control, and their interactions; with antigen processing and presentation, immunogenesis, and tolerogenesis; with cytokines, complement, neuroendocrine, and "psychoneuroimmunologic" relationships; and with the role of viruses in immunopathologic disorders of the nervous system. Primarily Antibody-Mediated "autoimmune" disorders will include: myasthenia gravis, Guillain Barre disease, and paraneoplastic disorders. Primarily Cell-Mediated 'autoimmune" disorders will include: acute post-infectious encephalomyelitis, multiple sclerosis, and chronic inflammatory diseases of the eye, the autonomic nervous system, and muscle. Additional lectures will deal with Persistent Viral Infections of the nervous system and chronic inflammatory disorders of the CNS related to immune dysfunction, such as: HTLV- 1-associated myelopathy, progressive multifocal leukoencephalopathy, SSPE, nervous system manifestations of AIDS, and Alzheimer's disease. The presentations will deal with mechanisms underlying disease process and lesion formation, and with their physiologic consequences. The sessions will be supplemented by demonstrations of patients with typical neuroimmunologic disease at health care institutions and of relevant viral and autoimmune models in animals.