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Mechanisms of gene expression changes in lung cancer

Mechanisms of gene expression changes in lung cancer
肺癌基因表达变化的机制
批准号：
6954043
负责人：
Jin Jen
金额：
$0.0万
依托单位：
DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6954043
关键词：
animal breeding biological signal transduction cooperative study disease /disorder model gene expression gene induction /repression genetic models genetic susceptibility genetically modified animals laboratory mouse life cycle lung neoplasms model design /development neoplasm /cancer genetics neoplastic transformation protein structure function transfection transforming growth factors

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中文摘要
翻译
我们正在继续努力开发体内和体外模型，以更好地了解肺癌中高度差异表达的基因的机制作用。我们已经产生了携带PGP9.5基因的转基因小鼠，这种基因在肺癌中经常过度表达。我们将密切检查这些转基因动物的潜在肿瘤形成、寿命变化，并将它们与其他肺癌动物模型进行繁殖。我们还在使用体内组织培养系统，通过转基因的质粒构建和siRNA技术来操纵目标基因的表达。
英文摘要
We are continuing our efforts to develop in vivo and in vitro models to better understand the mechanistic role of genes highly differentially expressed in lung cancers. We have generated transgenic mice carrying a gene, PGP9.5, which is often over expressed in lung cancers. We will closely examine these transgenic animals for potential tumor formation, life span changes, and to breed them with other lung cancer animal models. We are also using in vivo tissue culture systems to manipulate the expression of target genes using transfected plasmid constructs and siRNA technology.
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会议论文
Transcriptome map in non-small cell lung cancer
Gene expression profiles in lung cancer using cDNA array
Mechanisms of gene expression changes in lung cancer
Development of non-small cell lung cancer tissue microar
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