"Smart Food" - The fulcrum in the energy balance equation

该项目的总体目标是确定营养素如何最好地促进能量消耗的增加，从而减轻体重。这些实验将在老鼠身上进行，使用复杂的技术将特定的脂肪、碳水化合物或蛋白质组合直接引入胃中，然后测量一种特殊类型的能量燃烧的能量消耗，而不是储存脂肪的能量，称为棕色脂肪组织。这些实验将揭示与胃中营养物质和棕色脂肪组织激活有关的机制。他们将提供一个框架，该项目可以在此基础上建立关于智能饮食的知识，从而通过调节能量消耗来有效控制体重。

The overall aim of the project is to establish how nutrients best promote an increase in energy expenditure and therefore weight loss. The experiments will be performed in rats using sophisticated technologies to introduce specific combinations of fats, carbohydrates or proteins directly into the stomach and then measure energy expenditure in a specialised type of energy burning rather than energy storing fat called brown adipose tissue. These experiments will uncover the mechanisms that relate nutrients in the stomach and activation of brown adipose tissue. They will provide a framework on which this project can build a knowledge of smart diets that will allow the effective control of body weight through modulation of energy expenditure.