6th International Skin Carcinogenesis Conference

描述(申请人提供)：分子生物学的最新技术进步，包括转基因和基因敲除技术的发展，使人们对皮肤肿瘤发展过程中发生的遗传和表观遗传变化的性质有了更多的了解。这些进展极大地改进和扩展了我们对正常细胞癌变机制的概念。目前正在阐明内在遗传因素和外部修饰物的作用。这导致确定了预防和治疗的几个目标，尽管还需要取得更多进展。第六届国际皮肤癌变大会的目标是提供一个论坛，交流有关非黑色素瘤和黑色素瘤皮肤肿瘤发展过程中发生的生物学、细胞和分子变化的最新和相关信息。会议将集中于了解可能影响皮肤癌易感性的遗传因素，正常细胞信号和增殖的变化如何影响特定基因变化的表达，以及内在和外在因素如何改变肿瘤过程。 这个正在进行的两年一次的皮肤癌会议之所以重要，有两个原因。多阶段癌变的小鼠皮肤范例已经成为一个发现的模型，其中遗传和表观遗传改变适用于许多(如果不是全部)人类上皮性癌。这是一次互动性很强的会议，预计将产生并分享新的概念和想法，这些概念和想法将对皮肤癌的预防和干预产生影响。由于世界范围内黑色素瘤和非黑色素瘤皮肤癌的发病率都在增加，因此需要新的皮肤癌预防和治疗方法。这次会议旨在汇聚来自美国、欧洲和日本主要实验室的大约80-100名研究人员，他们积极参与皮肤癌发展和预防机制的尖端研究。会议将与蒙塔尼亚皮肤生物学研讨会联合举行。

DESCRIPTION (provided by applicant): Recent technical advances in molecular biology, including the development of transgenic and gene knockout technologies, have led to increased understanding of the nature of the genetic and epigenetic changes that occur in the development of skin tumors. These advances are greatly improving and expanding our concept of the mechanisms by which normal cells progress to malignancy. The role of both intrinsic genetic factors and external modifiers are now being elucidated. This has led to the identification of several targets for prevention and for therapy, although considerably more advances are needed. The goal of the 6th International Skin Carcinogenesis Conference is to provide a forum for exchange of the most recent and relevant information on the biological, cellular and molecular changes that occur during nonmelanoma and melanoma skin tumor development. Sessions will focus on understanding the genetic factors that can influence skin cancer susceptibility, how alterations in normal cell signaling and proliferation affect the expression of particular genetic alterations, and how intrinsic and extrinsic factors can modify the neoplastic process. This ongoing biannual skin carcinogenesis conference is important for two reasons. The mouse skin paradigm for multistage carcinogenesis has served as a model of discovery where the genetic and epigenetic alterations are applicable to many if not all human epithelial cancers. This is a very highly interactive meeting where it is anticipated that new concepts and ideas will be generated and shared that will have an impact on the prevention and intervention in skin cancer development. Because there is a world-wide increase in the incidence of both melanoma and nonmelanoma skin cancers, new approaches to skin cancer prevention and treatment are needed. This meeting is intended to bring together approximately 80- 100 researchers from major laboratories in the United States, Europe and Japan that are actively engaged in cutting-edge research on the mechanisms of skin cancer development and prevention. The meeting will be held jointly with the Montagna Symposium on the Biology of Skin.