FASEB Summer Conference: Folate, B12 and 1C Metabolism

描述（由申请人提供）： 要求提供资金，以部分支持将于2004年7月31日至8月5日在科罗拉多斯诺马斯村举行的第10届FASEB叶酸、维生素B12和一碳代谢夏季会议。本次会议为临床研究人员，基础科学家和参与健康和科学政策的人员之间进行富有成效的，正式和非正式的互动提供了一个独特的机会。与会者代表了不同和广泛的学科。前九次会议每两年举行一次，会议的名额都已全部订满。本次会议将限于210名与会者。所要求的资金将用于支持研究生、住院医生、博士后研究员以及知名的国家和国际调查人员的出席。一个由资深科学家领导的详细计划强调了新进入该领域的初级科学家的参与。选定的会议和研讨会主题涵盖基础科学和临床研究，特别强调两者之间的相互作用和潜在的协同作用。具体课程包括：（1）一碳代谢：酶学，途径，区室化和调节，（2）一碳代谢和遗传变异，（3）甲硫氨酸代谢：整合途径内的调节，（4）同型半胱氨酸毒性的病理生理学，（5）一碳代谢、表观遗传学和发育，（6）钴胺素、叶酸和蛋氨酸代谢的先天性缺陷，（7）钴胺素转运和代谢的化学和临床进展，（8）一碳代谢，甲基化和肿瘤，（9）叶酸强化：结果评估。研讨会将提供专家和当前的分析：（1）叶酸，同型半胱氨酸和心血管疾病：临床试验的结果，（2）holoTC作为维生素B12缺乏症的早期标志物的临床效用，（3）高同型半胱氨酸血症和认知功能障碍和（4）药物基因组学。 这种形式鼓励主持人和研究员、住院医生和初级研究人员之间进行讨论。同样，海报会议也突出了年轻参与者的活动和需求。

DESCRIPTION (provided by applicant): Funds are requested for partial support of the 10th FASEB summer conference on Folic Acid, Vitamin B12 and One-Carbon Metabolism to be held July 31 to August 5, 2004 at Snowmass Village, Colorado. This conference offers a unique opportunity for productive, formal and informal interactions between clinician investigators, basic scientists and those involved in health and science policy. The participants represent a diverse and broad range of disciplines. The previous nine conferences, which met every second year, were fully subscribed. The current conference will be limited to 210 participants. The requested funds will support the attendance of graduate students, resident physicians, postdoctoral fellows and established national and international investigators. A detailed program, led by senior scientists, emphasizes the participation of junior scientists new to the field. The selected session and workshop topics cover the basic sciences and clinical research with particular emphasis on the interaction and potential synergy between the two. The specific session subjects include: (1) One Carbon Metabolism: Enzymology, Pathways, Compartmentation and Regulation, (2) One-Carbon Metabolism and Genetic Variation, (3) Methionine Metabolism: Regulation within the Integrated Pathway, (4) Pathophysiology of Homocysteine Toxicity, (5) One-Carbon Metabolism, Epigenetics and Development, (6) Inborn Errors of Cobalamin, Folate and Methionine Metabolism, (7) Chemical and Clinical Advancements in Cobalamin Transport and Metabolism, (8) One-Carbon Metabolism, Methylation and Neoplasia, (9) Folate Fortification: Assessment of Outcomes. The workshops will provide expert and current analyses of: (1) Folic acid, homocysteine and cardiovascular disease: results from clinical trials, (2) The clinical utility of holoTC as an early marker of vitamin B12 deficiency, (3) Hyperhomocysteinemia and cognitive dysfunction and (4) Pharmacogenomics. The format encourages discussions among the presenters and the fellows, residents and junior investigators in attendance. Similarly, the poster sessions also highlight the activities and needs of the younger participants.