Cancer Prevention: Translation of Molecular Revolution

描述(由申请者提供)：为题为“癌症预防：将分子革命翻译到临床”的科学研讨会申请会议资助。研讨会将于2004年5月4日至6日在以色列海法的丹·卡梅尔酒店举行。该讲习班的组委会由Dean Brenner博士(美国)、Gad Rennert博士(以色列)、Lawrence Freedman博士(以色列)和Jaak Janssens博士(比利时)组成。本次会议的目标是： 1.将新的生物标记物发现方法与分子和人群流行病学以及癌症风险评估的洞察力联系起来。 2.回顾来自新的靶向化学预防药物和组合的最新数据，以开发在基于遗传和基于人群的癌症风险评估的基础上确定的组中使用生物标记物靶标进行临床测试的新范例。 3.促进来自美国、中东和欧洲的科学家之间的合作，开发新的方法来干预乳腺癌和结直肠癌发展的高风险对象。 邀请与会者的依据是他们在科学学科方面的多样性、互动和合作的经验和记录，以及他们被认为愿意改变先入为主的观念，以适应新的信息和重新制定未来的研究计划。这次会议气氛紧张，仿效戈登会议。它要求与会者作为一个小组保持隔离三天，密切合作。用餐和空闲时间的安排是为了增加与会者进行非正式互动的机会。本会议的特点是限量20分钟的讲座或45分钟的全体讲座，频繁的讨论时段，45至90分钟的多次小组讨论，长时间的午餐和晚餐时间，重点突出的小组会议，以及会议结束时的“白皮书”，以创造闭幕和重点的需要。白皮书和演讲者论文将在适当的同行评审后提交发表在《癌症流行病学、生物标记物和预防》杂志上。通过密集的互动，与会者将相互熟悉，将了解会议上代表的不同学科的优势和劣势，并将认识到并建立跨学科互动，以创造必要的科学关键群体来推动该领域的发展。

DESCRIPTION (provided by applicant): Meeting grant support is requested for a scientific workshop entitled "Cancer Prevention: Translation of the Molecular Revolution to the Clinic". This workshop will be held in the Dan Carmel Hotel in Haifa, Israel, on May 4-6, 2004. The organizing committee for this workshop consists of Drs. Dean Brenner (USA), Gad Rennert (Israel), Lawrence Freedman (Israel) and Jaak Janssens (Belgium). The objectives of this conference are: 1. To link new biomarker discovery methodologies with molecular and population epidemiologic and insights upon cancer risk assessment. 2. To review recent data from new targeted chemopreventive agents and combinations to develop new paradigms of clinical testing using biomarker targets in groups identified on the basis of genetic and population based cancer risk assessment. 3. To promote collaborations among scientists form the United States, the Middle East and Europe to develop novel approaches to intervene in subjects at high risk for the development of breast and colorectal cancer. Conferees are invited based upon their diversity in scientific discipline, interactive and collaborative experience and track-record, and perceived willingness to alter preconceptions in order to accommodate new information and reformulate future research plans. The Conference is intense and modeled after the Gordon Conferences. It requires conferees to remain segregated as a group for three days, working closely together. Meals and free time are structured to enhance the opportunities of conferees to interact informally. The Conference features a limited number of 20 minute lectures or 45 minute plenary lectures, frequent discussion periods, multiple 45 to 90 minute panel discussions, long lunch and dinner periods with focused group meetings, and an end of conference "White Paper" to create the need for closure and focus. The White Papers and speaker papers will be submitted for publication in Cancer Epidemiology, Biomarkers and Prevention after appropriate peer review. By intensively interacting, conferees will become familiar with each other, will understand the strengths and weaknesses of the diverse disciplines represented at the meeting, and will recognize and establish cross disciplinary interactions to create necessary scientific critical masses to advance the field.