Jaks and Stats: Development to Disease

描述（由申请人提供）：Jak-Stat信号通路的研究现已达到极其复杂的水平。 然而，重要的新见解继续迅速出现，涉及新的途径组分或已知途径组分的新作用，这些组分对通过Jak-Stat途径以及其他信号传导途径的信号传导具有深远影响。 最近的工作还表明，Jak和Stats是进化上保守的信号传导分子，其调节从干细胞更新和胚胎发生到造血和淋巴细胞的器官发生和发育的多种基本过程。 此外，它们在预防或促进传染性、恶性和自身免疫性疾病中的作用现在已经成为深入研究的领域，并且在这些领域中正在取得令人兴奋的新发现，这些发现广泛适用于生物学的几个领域。 本次会议的目标如下：（1）确定Jak-Stat通路成员之间的新型相互作用，不仅相互之间，而且与其他信号转导通路的受体和组分之间的相互作用，特别强调调节Jak-Stat通路信号传导的正作用和负作用机制;（2）确定Jak的角色-原始和高等生物发育中的Stat途径及其组成部分，特别强调模型遗传生物以及造血和免疫系统;（3）讨论Jak-Stat信号通路在感染性疾病和肿瘤性疾病中的各种保护作用与疾病促进作用。

DESCRIPTION (provided by applicant): The study of the Jak-Stat signaling pathway has now reached an extremely sophisticated level. Nevertheless, significant new insights continue to rapidly emerge involving either novel pathway components or novel actions of known pathway components that have profound influences on signaling through both the Jak-Stat pathway as well as other signaling pathways. Recent work has also shown that Jak and Stats are evolutionarily conserved signaling molecules that regulate a diverse group of fundamental processes ranging from stem cell renewal and embryogenesis to organogenesis and development of hematopoietic and lymphoid ceils. Furthermore their roles in preventing or promoting infectious, malignant and autoimmune diseases have now become areas of intense study and exciting new findings are being made in these areas that have wide applicability to several fields of biology. The goals of this meeting are as follows: (1) Identify novel interactions between members of the Jak-Stat pathway not only with one another but also with receptors and components of other signal transduction pathways with special emphasis on positive and negative acting mechanisms that regulate Jak-Stat pathway signaling; (2) Define the roles of the Jak-Stat pathway and its components in development of primitive and higher organisms with special emphasis being placed on model genetic organisms and on the hematopoietic and immune systems; and (3) Discuss the various protective versus disease-promoting effects of the Jak-Stat signaling pathway in infectious and neoplastic diseases.