OptoAcoustic and Ultrasonic Imaging of Angiogenesis

描述(由申请人提供)： 该提案首次将光声和超声血管生成成像技术结合到一台仪器中。配备光纤的I-2 MHz相控阵超声探头将在反向模式下工作。在这种方法中，超声图像和光声图像将在空间上叠加，然后在一些表示中进行融合。超声图像包括B型、彩色血流多普勒、能量多普勒和频谱多普勒。堆叠式换能器将在接收时将声谱能力提高一倍至24 MHz，以实现对新生血管中非常小的血管的可视化。 OPO激光器将从红外波长的光谱中提供窄波长，以光度方式选择不同的化合物，以吸收、膨胀和发射超声波。对小血管区域的氧合/脱氧血红蛋白的估计将以图像叠加的形式显示。 这一独特的仪器在光声学中区分血液，在超声波中区分组织，从而实现非常高的血管分辨率、血管流量(特别是不受壁面运动干扰的低流量)及其含氧量。 WinProbe的科学研究平台将针对这种新的模式组合进行优化，并将实时产生融合图像。 这项建议包括对已知抗血管生成药物作用下的小鼠血管生成进行成像和定量评估的临床研究。其目标是将一种用于临床研究的仪器商业化。 血管生成在癌症中的作用在文献中得到了很好的证明，该仪器有望对癌症科学研究做出重大贡献。 预计未来的商业产品将在内窥镜仪器中跟进，以帮助检测癌症，因为光学评估仅限于表面，缺乏对比度。

DESCRIPTION (provided by applicant): This proposal for "Optoacoustic and Ultrasonic Imaging of Angiogenesis" combines optoacoustics and ultrasound in a single instrument for the first time. A I 2MHz phased array ultrasound probe equipped with fiber optics for delivery of laser illuminations will operate in the backwards mode. In this method the ultrasonic image and the optoacoustic image will be spatially overlaid and then fused in some presentations. The ultrasonic images will include B-Mode, color Flow Doppler, power Doppler and Spectral Doppler. A stacked transducer will double the acoustic spectral capabilities to 24 MHz on reception to attain visualization of very small vessels in the neovascuIarization. An OPO laser will provide a narrow wavelength from a spectrum of Infra Red wavelengths of light to photometrically select different compounds for light absorption, expansion and emission of ultrasound. Estimation of the oxy / deoxy hemoglobin in small vascular regions will be displayed as an image overlay. This unique instrument differentiates blood in optoacoustics, and tissue in ultrasound, allowing very high resolution of blood vessels, their flow (especially low flow without interference of wall motion) and their oxygen content. WinProbe's Scientific Research Platform will be optimized for this new combination of modalities and will produce fused images in real time. This proposal includes clinical studies to image and quantitatively access angiogenesis in mice under the effect of known anti-angiogenesis drugs. The goal is to commercialize an instrument for clinical research. The role of angiogenesis in cancer is well documented in the literature and this instrument can be expected to make a significant contribution to the science of cancer research. Future commercial products are expected to follow in endoscopic instruments to assist in the detection of cancer where optical assessments are limited to the surface and are contrast deprived.