Midcareer Award in Patient-Oriented Research

描述(由申请人提供)：这项职业生涯中期临床研究研究员奖的目的是为阿拉巴马大学伯明翰分校(UAB)医学院妇产科教授约翰·欧文(John Owen，M.D.)提供足够的保护时间，以1)继续并扩大他正在进行的临床研究活动，包括担任一项资助的U01多中心随机环扎试验的首席研究员，以防止自发早产；2)增强他作为导师和教育者的能力，特别是通过完成临床研究的公共卫生硕士学位并获得UAB生物统计系的双重任命；以及3)继续通过妇产科住院医生的研究计划，特别是通过他作为UAB母婴医学研究金项目主任的职位，确定和培训专注于学术的个人。他获得新技能的重点将是在最近由公共卫生学院和生物统计学院联合推出的一个新的研究生课程中完成临床研究公共卫生硕士学位。它特别针对NIH最近的目标，通过结合生物统计学和公共卫生课程的选定方面来扩大合格的临床研究人员队伍，提供更广泛和更务实的教育经验。有了这个高级学位，欧文博士可以放心地在生物统计学院获得双重任命，并将在这个有价值的项目中承担正式的、持续的教学承诺。此外，作为最近资助的U01拨款的私人投资者，他将在妊娠中期宫颈长度较短的高危女性身上进行一项多中心随机环扎试验，他将处于战略地位，可以在多胎妊娠的妇女中启动类似的试验，并获得作为随机试验一部分的生物体库分析资金。这将增加我们对反复自然早产的机制的理解，也为欧文博士可以与其他年轻研究人员合作从而培训其他年轻研究人员的多个研究项目提供基础。总而言之，上述举措，加上他作为母胎医学研究金和妇产科住院研究部主任的职位，以及职业生涯中期调查员奖的保障，将确保他的教育和经验将通过不断促进其他研究事业来传播。

DESCRIPTION (provided by applicant): The purpose of this Mid-career Investigator Award in Clinical Research is to provide John Owen, M.D., Professor of Obstetrics and Gynecology in the School of Medicine at the University of Alabama at Birmingham (UAB) with sufficient protected time to 1) continue and expand his ongoing clinical research activities including serving as the principal investigator of a funded U01 multicenter randomized trial of cerclage for the prevention of spontaneous preterm birth; 2) enhance his capabilities as a mentor and educator, especially through the completion of an MPH in Clinical Research and receipt of a dual appointment in the Department of Biostatistics at UAB; and 3) continue to identify and train academically focused individuals through research initiatives in the Ob/Gyn residency and particularly through his position as the Maternal-Fetal Medicine fellowship program director at UAB. The focus of his new skills acquisition will be the completion of an MPH in Clinical Research in a novel post-graduate program recently introduced jointly by the schools of Public Health and Biostatistics. It specifically addresses recent NIH goals to expand the pool of qualified clinical investigators by combining selected aspects of both the Biostatistics and Public Health curricula, offering a broader and more pragmatic educational experience. With this advanced degree, Dr. Owen can be assured of a dual appointment in the School of Biostatistics and will assume a formal, ongoing teaching commitment in this valuable program. Moreover, as the P.I. of a recently funded U01 grant to conduct a multicenter randomized trial of cerclage in high-risk women with shortened mid-trimester cervical length, he will be in a strategic position to launch a similar trial in women with multiple gestation and also to receive funding for the analysis of the biologic fluid bank planned as part of the randomized trial. This will increase our understanding of the mechanisms of recurrent spontaneous preterm birth and also provide the basis for multiple research projects through which Dr. Owen can collaborate with and thereby train other young investigators. In summary, the above-stated initiatives, coupled with his position as the director of both the Maternal-Fetal Medicine fellowship and the obstetric in-patient research unit at UAB, and secured by the Mid-career Investigator Award, will ensure that his education and experience will be propagated by continuously fostering other research careers.