Genetic and Developmental Mechanisms of Pediatric Disea*

描述(由申请人提供)：本申请描述了犹他大学的CHRCDA项目。该计划广泛关注儿科疾病的遗传和发育机制，使这项研究和教育计划涵盖所有儿科学科。这项申请整合了犹他大学和儿科系的资源，以建立一个新的、多学科的计划，为有前途的内科科学家在学术儿科的职业生涯做准备。该计划独有的资源包括研究导师、埃克尔斯人类遗传学研究所、犹他州出生缺陷网络和犹他州人口数据库的既定记录，犹他州人口数据库是一个拥有300多万条记录的广泛的家谱数据库。该计划将使来自几个项目和部门的富有成效、资金充足的研究人员能够参与儿科医生-科学家的教育。该项目的导师和顾问来自人类分子生物学项目、神经生物学和解剖学系、霍华德·休斯医学研究所、亨斯迈癌症研究所、病理学系、生物系、人类遗传学系和儿科。有前途的学者将从现有的教员、研究员和有针对性的招聘人员中挑选出来。通过NIH资助的人类疾病遗传基础培训计划，教学材料将提供生物统计学、研究设计、伦理问题、分子生物学、遗传学和医学写作方面的研究生水平教育。该计划将使儿科系能够提供对培养成功的儿科内科医生-科学家至关重要的教育和受保护的指导研究支持。

DESCRIPTION (provided by applicant): This application describes the CHRCDA program of the University of Utah. This program focuses broadly on the genetic and developmental mechanisms of pediatric disease, allowing this research and educational program to encompass all pediatric disciplines. This application integrates the resources of the University of Utah and the Department of Pediatrics to establish a new, multidisciplinary program that will prepare promising physician-scientists for careers in academic pediatrics. Resources unique to this program include the established records of the research mentors, the Eccles Institute of Human Genetics, the Utah Birth Defects Network, and the Utah Population Database, an extensive genealogical database with more than 3 million records. The program will enable productive, well-funded investigators from several programs and departments to participate in the education of pediatric physician-scientists. Mentors and advisors for this program have been selected from the Program in Human Molecular Biology, the Department of Neurobiology and Anatomy, the Howard Hughes Medical Institute, the Huntsman Cancer Institute, the Department of Pathology, the Department of Biology, the Department of Human Genetics, and the Department of Pediatrics. Promising scholars will be selected from current faculty, fellows, and targeted recruitments. Didactic material, facilitated through an NIH-funded training program in the Inherited Basis of Human Disease, will provide graduate level education in biostatistics, study design, ethical issues, molecular biology, genetics, and medical writing. This program will enable the Department of Pediatrics to provide the education and protected mentored research support essential to the development of successful pediatric physician-scientists.