Genetic and Developmental Mechanisms of Pediatric Disease

儿科疾病的遗传和发育机制

• 批准号: 8197130
• 负责人: Edward Bowersox Clark
• 金额: $ 43.2万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-11 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8197130
• 关键词: Award; Biometry; Child health care; Childhood; Developmental Biology; Disease; Educational Curriculum; Environment; Epidemiology; Exploratory/Developmental Grant for Diagnostic Cancer Imaging; Faculty; Funding; Goals; Grant; Instruction; K-Series Research Career Programs; Laboratories; Lead; Medical Genetics; Mentors; Molecular Biology; Molecular Genetics; Physicians; Research; Research Ethics; Research Methodology; Research Personnel; Resources; Scientist; Series; Structure; Training; United States National Institutes of Health; Universities; Utah; Writing; career; data management; developmental genetics; didactic education; experience; improved; innovation; medical schools; member; pediatric department

The Department of Pediatrics of the University of Utah proposes the continuation of its highly successful training program¿the Utah Child Health Research Career Development Award (CHRCDA) program. The Utah CHRCDA selects the most outstanding junior faculty scholars for rigorous scientific training in a robust research environment. The Utah CHRCDA uses experienced basic- and physician-scientists as mentors to provide the expertise, guidance, and laboratoryfacilities that enable scholars to launch successful careers as physician-scientists. The overarching theme of the Utah CHRCDA, the genetic and developmental mechanisms that underlie pediatric disease, offers rich opportunities for research and discovery that will lead to improved health for children. Highly-promising scholars are selected from graduating fellows who join the Department, by faculty recruitment or from current junior faculty. Mentored experiences in the laboratories of established, NIH-funded investigators enable scholars to apply innovative research methods to molecular genetics and developmental biology. A structured curriculum (supported by a K30 award to the University's School of Medicine) offers scholars a graduate-level didactic education in epidemiology, biostatistics, data management, medical genetics, and molecular biology. Senior pediatric faculty members provide formal instruction in scientific writing, grant writing and research ethics. Utah scholars have made exceptional progress during the first four years of the current CHRCDA program. Four of the first six scholars received K series awards; one scholar has received an R21 award; and one scholar has a pending resubmission of a K08 application. These results indicate that the resources entrusted to the University of Utah and the Department of Pediatrics have been used effectively to mentor the research careers of young faculty members and fulfill the goals of the CHRCDA program.

犹他州大学儿科系建议继续其非常成功的 培训计划犹他州儿童健康研究职业发展奖（CHRCDA）计划。的 犹他州CHRCDA选择最优秀的初级教师学者进行严格的科学培训， 研究环境。犹他州CHRCDA使用经验丰富的基础-和医生-科学家作为导师， 提供专业知识，指导和实验室设施，使学者能够启动成功的职业生涯， 物理科学家犹他州CHRCDA的首要主题是遗传和发育 儿童疾病的潜在机制，为研究和发现提供了丰富的机会， 以改善儿童的健康。非常有前途的学者是从毕业的研究员谁加入 系，通过教师招聘或从现有初级教师中招聘。实验室的指导经验 NIH资助的研究人员使学者能够将创新的研究方法应用于分子生物学。 遗传学和发育生物学。一个结构化的课程（由K30奖支持，以大学的 医学院）为学者提供流行病学，生物统计学，数据 管理学、医学遗传学和分子生物学。高级儿科教师提供正式的 在科学写作，授予写作和研究道德的指导。犹他州的学者们 在目前的CHRCDA方案的前四年取得的进展。前六位学者中有四位获得了K 一名学者获得了R21奖;一名学者正在重新提交一份研究报告。 K 08应用程序。这些结果表明，委托给犹他州大学和 儿科系已被有效地用于指导年轻教师的研究生涯 成员和实现CHRCDA计划的目标。

项目成果

Traumatic brain injury during development reduces minimal clonic seizure thresholds at maturity.

发育过程中的创伤性脑损伤会降低成熟时的阵挛性癫痫发作的最低阈值。

• DOI: 10.1016/j.eplepsyres.2008.04.001
• 发表时间: 2008
• 期刊: Epilepsy research
• 影响因子: 2.2
• 作者: Statler,KimberlyD;Swank,Seth;Abildskov,Tracy;Bigler,ErinD;White,HSteve
• 通讯作者: White,HSteve

Glutathione s-transferases in pediatric cancer.

• DOI: 10.3389/fonc.2011.00039
• 发表时间: 2011
• 期刊: Frontiers in oncology
• 影响因子: 4.7
• 作者: Luo W;Kinsey M;Schiffman JD;Lessnick SL
• 通讯作者: Lessnick SL

Clindamycin-resistant group B Streptococcus and failure of intrapartum prophylaxis to prevent early-onset disease.

• DOI: 10.1016/j.jpeds.2009.10.048
• 发表时间: 2010-03
• 期刊: JOURNAL OF PEDIATRICS
• 影响因子: 5.1
• 作者: Blaschke, Anne J.;Pulver, Laurie S.;Korgenski, E. Kent;Savitz, Lucy A.;Daly, Judy A.;Byington, Carrie L.
• 通讯作者: Byington, Carrie L.

EPO improved neurologic outcome in rat pups late after traumatic brain injury.

• DOI: 10.1016/j.braindev.2018.01.003
• 发表时间: 2018-05
• 期刊: Brain & development
• 影响因子: 1.7
• 作者: Schober ME;Requena DF;Rodesch CK
• 通讯作者: Rodesch CK

Zebrafish foxP2 zinc finger nuclease mutant has normal axon pathfinding.

• DOI: 10.1371/journal.pone.0043968
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Xing L;Hoshijima K;Grunwald DJ;Fujimoto E;Quist TS;Sneddon J;Chien CB;Stevenson TJ;Bonkowsky JL
• 通讯作者: Bonkowsky JL