Integrative Neuroscience Initiative on Alcoholism

描述（由申请人提供）： 长期接触酒精会导致神经适应现象，包括 耐受性、敏感性、依赖性、戒断、饮酒失控， 和复发，导致过度饮酒的发展 消费本申请为一个财团的“综合 酒精中毒神经科学倡议”（MA）（RFA：AA-01-002）旨在确定 分子，细胞，和行为神经适应发生在 大脑奖赏回路与扩展杏仁核及其 连接.据推测，遗传差异和/或 这个回路中的神经适应是个体 对过度饮酒的脆弱性的差异。我们 目标是：1）。建立动物模型研究特异性神经生物学 导致过度饮酒的脆弱性指标 分子、细胞和神经回路水平的分析。2）。以识别 特定的基因簇，其表达受酒精调节， 负责任何给定的模型过量饮酒使用 基因表达阵列，差异显示，特异性突变 大脑区域，并开发新的信息学工具来分析和 解释基因表达、细胞回路和脑回路数据， 使用转基因和敲除方法。3）。为了吸引新的和 通过招募创新的研究人员到酒精研究领域， 个人发展UOI赠款和试点项目，并通过发展 INIA科学家和其他人之间的在线互动能力， 神经信息学集成数据集可访问，可搜索， 与其他数据库互动，供所有对酗酒感兴趣的科学家使用 research.环境影响评价协会的结构设想为三个分组， 整合了三个领域：依赖的动物模型和 神经适应亚组，神经回路亚组，和分子基础 过度饮酒亚组。在每个域中建立核心设施 包括遗传动物模型核心、基因表达核心和 图像核心，分别。每个小组由4-5个UOI提案组成 和1-3个发展性UOI研究提案。试点项目计划是 建议确定令人兴奋的新研究领域，并继续 为酒精领域征聘新的调查员。INIA计划将 由一个行政核心在与综合办事处密切合作下指导， 神经信息学核心通过指导委员会和持续的建议 科学咨询委员会的。

DESCRIPTION (provided by applicant): Chronic exposure to alcohol results in neuroadaptive phenomena, including tolerance, sensitization, dependence, withdrawal, loss of control of drinking, and relapse that contribute to the development of excessive alcohol consumption. This application for a Consortium for the "Integrative Neuroscience Initiative on Alcoholism" (MA) (RFA: AA-01-002) is to identify the molecular, cellular, and behavioral neuroadaptations that occur in the brain reward circuits associated with the extended amygdala and its connections. It is hypothesized that genetic differences and/or neuroadaptations in this circuitry are responsible for the individual differences in vulnerability to the excessive consumption of alcohol. Our goals are: 1). To establish animal models to study specific neurobiological targets for vulnerability that lead to excessive consumption of alcohol at the molecular, cellular and neural circuit levels of analysis. 2). To identify specific clusters of genes whose expression is regulated by alcohol and which are responsible for any given model of excessive alcohol consumption using gene expression arrays, differential display, mutagenesis directed at specific brain areas, and the development of new informatics tools to analyze and interpret gene expression, cellular circuitry and brain circuitry data and with the use of transgenic and knockout approaches. 3). To attract new and innovative investigators to the field of alcohol research by recruiting individuals for developmental UOI grants and pilot projects and by developing online interactive capacity among INIA scientists and others, and by making the neuroinformatics integrated data sets accessible, searchable and interactive with other databases for all scientists interested in alcoholism research. The structure of EIUA is envisioned as three subgroups that integrate across three domains: Animal Models of Dependence and Neuroadaptation Subgroup, Neurocircuitry Subgroup, and Molecular Basis of Excessive Drinking Subgroup. Core facilities are established in each domain and include the Genetic Animal Models Core, the Gene Expression Core and the Imaging Core, respectively. Each Subgroup is comprised of 4-5 UOI proposals and 1-3 Developmental UOI research proposals. A Pilot Project program is proposed to identify exciting new areas for research and the continual recruitment of new investigators to the alcohol field. The INIA program will be directed by an Administrative Core in close cooperation with the Integrated Neuroinforinatics Core via a Steering Committee and with the continual advice of the Scientific Advisory Committee.