SAN ANTONIO CENTER OF BIOMARKERS OF RISK FOR PROSTATE CA

描述：(申请人描述) 前列腺癌是美国男性最常见的癌症。这种疾病有一种 与种族背景的独特联系-发病率最高和 非洲裔美国人的死亡风险，这是 欧洲裔美国人，而拉美裔美国人的风险明显较低，特别是 墨西哥裔美国人在拉美裔美国人中所占比例最大 美国的一些假说可以解释这些差异，包括饮食 因素、微量营养素的使用和遗传差异--特别是那些 改变雄激素受体的反应。这个节目，圣安东尼奥 前列腺癌风险生物标记中心(Sabor)将利用 五个机构合作，接触到大量的民族 少数族裔将进行前列腺癌系列检查，检查 风险和结果的生物标记物，并将这些数据与广泛的 强大的临床数据库。待检测的特定生物标志物包括IGF-1， IGFBP-3和-4，雄激素受体三核苷酸重复长度，以及 营养分析和硒暴露。这一种族多元化 人口、生物信息库和临床数据库系统将重点放在 这些独特的前列腺癌风险因素将带来这些独特的和 为早期发现中的调查人员网络提供宝贵资源 研究网络。

DESCRIPTION: (Applicant's Description) Prostate Cancer is the most common cancer in U.S. men. The disease has a unique association with ethnic background - the highest incidence and mortality risk in African Americans, an intermediate risk in European-Americans, and a significantly lower risk among Hispanics, notably Mexican Americans who constitute the largest proportion of Hispanics in the U.S. A number of hypotheses may explain these differences including dietary factors, micronutrient use, and genetic differences - especially those that modify the response of the androgen receptor. This program, the San Antonio Center of Biomarkers of Risk for prostate cancer (SABOR) will leverage the collaboration of five institutions with access to large numbers of ethnic minorities to conduct serial examinations for prostate cancer, examine biomarkers of risk and outcome, and to link these data with an extensive, robust clinical database. Specific biomarkers to be examined include IGF-1, IGFBP-3 and -4, androgen receptor trinucleotide repeat length, as well as nutritional analyses and selenium exposure. This ethnically-diverse population, the biorepository, and clinical database system will focus upon those unique factors of prostate cancer risk and will bring these unique and valuable resources to the network of investigators in the Early Detection Research Network.