Fox Chase Cancer Center Breast Cancer Tissue Resources

描述（由申请人提供）： 由于缺乏足够数量的患者标本，以及缺乏足够的随访或患者信息，治疗方式的可变性以及计算机化系统不佳，无法检索进行这些研究所需的病例，因此阻碍了对肿瘤标志物的明确评价。因此，需要的是一种乳腺癌组织资源，其能够提供足够量的存档乳腺组织，以允许研究人员基于疾病的阶段、治疗方式、随访、适当的组织学诊断、淋巴结状态、肿瘤分级和其他人口统计学数据（例如年龄、绝经状态和种族等）得出有效的统计学结论。为了满足这些需求，我们组织了Fox Chase癌症组织资源（FCCC-BCTR）。FCCC-CBCTR是创建国家癌症研究所合作乳腺组织资源（NCI-CBCTR）的四大支柱之一。FCCC-BCTR在过去八年中为NCI-CBCTR数据库中的9，000个病例提供了2，859多个病例。收集的病例包含存档石蜡组织，人口统计学，病理学，临床，治疗和各自的临床随访数据。近年来，我们一直在开发组织芯片作为一种更有效的方式，提供大量的情况下，最少量的资源给研究人员。基于这一贡献，我们提出了以下具体目标，以维护作为NCI-CBCTR一部分的FCCC乳腺组织资源： 一曰：向研究者提供组织切片和相关临床数据，研究者的申请已由代表根据优点和内容建议批准并得到NCI-CBCTR的批准。这项工作将与NCI-CBCTR的其他资源合作进行。第二章：积极参与组织微阵列的构建，并进一步分发给REP和NCI-CBCTR推荐批准其申请的研究者。这项工作将与NCI-CBCTR的其他资源合作进行。3：保持新病例的充分累积，以便补充使用过的存档组织。第四章：构建正常乳腺组织的组织微阵列，并进一步分发给REP和NCI. CBCTR建议批准其申请的研究者。5：在FCCC-CBCTR中保持适当的质量控制。第六章：充分参与NCI合作乳腺癌组织资源协调委员会的运作，并与研究评估小组7合作：通过适当的营销举措鼓励利用NCI-CBCTR。

DESCRIPTION (provided by applicant): A definitive evaluation of tumor markers has been hindered by a lack of adequate number of patient's specimens and :the lack of adequate follow-up or patient information, the variability in therapeutic modalities, and poor computerization systems to retrieve the desired cases for performing these studies. Therefore, what is needed is a breast cancer tissue resource that would be able to provide archival breast tissue in sufficient amount to allow researchers to draw valid statistical conclusions, based on the stage of the disease, treatment modality, follow-up, adequate histological diagnosis, lymph node status, tumor grading and other demographic data such age, menopausal status and race among others. For answering these needs we have organized the Fox Chase Cancer Tissue Resources (FCCC-BCTR). The FCCC-CBCTR has been one of the four pillars for the creation of the National Cancer Institute Cooperative Breast Tissue Resources (NCI-CBCTR). The FCCC-BCTR has contributed during the last eight years with more than 2,859 cases to the total of 9,000 cases available in the NCI-CBCTR database. The collected cases contain the archival paraffin tissue, data on demography, pathology, clinic, treatment, and their respective clinical follow-up. Recently we have been developing the tissue microarray as a more efficient way to provide large amount of cases with minimal amount of resources to the researchers. Based on this contribution we propose the following specific aims for the maintenance of the FCCC Breast Tissue Resources as part of the NCI-CBCTR: 1: To provide tissue sections and pertinent clinical data to investigators whose applications have been recommended for approval by merit and content by REP and approved by the NCI-CBCTR. This work will be done in cooperation with the other resources of the NCI-CBCTR. 2: To actively participate in the construction of tissue microarray and further distribution to investigators whose applications have been recommended for approval by REP and by the NCI-CBCTR. This work will be done in cooperation with the other resources of the NCI-CBCTR. 3: To maintain an adequate accrual of new cases that allows a replenishment of the used archival tissue. 4: To construct tissue microarray of normal breast tissue and further distribution to investigators whose applications have been recommended for approval by REP and by the NCI.CBCTR. 5: To maintain an adequate quality control in the FCCC-CBCTR. 6: To fully participate in the functioning of the coordinating Committee of the NCI Cooperative Breast Cancer Tissue Resource and to collaborate with the Research Evaluation Panel 7: To encourage the utilization of the NCI-CBCTR through an adequate marketing initiative.