Core--Clinical resources

描述（由申请人提供）： 核心A将作为所有项目和核心的资源。其主要 目的是招募和重新审查950名成员的原始队列， 圣安东尼奥家庭心脏研究的参与者。考试将采取 在弗雷德里克C。巴特综合临床研究中心， 位于圣安东尼奥的奥迪墨菲纪念退伍军人医院。的 诊所检查将包括四个要素：核实和同意; 详细询问病史和生育史、药物和维生素 使用和生活方式行为;物理测量（心率、血液 压力和肥胖的各种评估）;和静脉切开术。的数据和 血液样本将被运送到西南生物医学基金会 核心A人员将进行的研究：编辑血液样本;进行生物化学 测量葡萄糖、胰岛素、胆固醇和甘油三酯浓度 和脂蛋白大小表型;并检查所有数据的可重复性， 在将数据文件提供给项目调查人员之前，必须确保一致性。 (End摘要） 由Rainwater博士领导的临床核心主要负责 收集数据和样本，处理和储存样本， 从血液样品和数据中测量大量表型 输入和验证。目前，共有809人被发现。 计划项目; 950人将在前四年返回 年SAFHS 3.考试将在Audie的GCRC举行 墨菲纪念退伍军人医院和所有用品的检查将 由GCRC提供。核心A人员将负责数据管理 和样品处理。调查人员已经表明，他们有能力 在后续研究中获得家庭成员的良好参与，并将 要格外努力地跟踪重要的血统成员。类似的电池 问卷和测量将被使用，因为是在以前使用 study.调查人员已决定不再跟进家庭信息 为了节省时间或许至少应该评估一下 不返回者的状况和健康状况。也是一 遗憾的是，颈动脉测量无法再次获得， 纵向研究，特别是因为最初的遗传性是如此之强， 然而，这可能非常昂贵和耗时。 这个核心是至关重要的成功项目作为一个整体，因为新的样品是 脂肪组织的内分泌功能所需， 表型在项目1中，氧化应激表型在项目2中。的 样本处理、样本储存、脂蛋白分析的一般方案 和质量控制都非常出色。 需要更多关于处理新样本的方案的信息 待测表型以及如何将样本转移到外部实验室 并将完成信息的返回。这个核心的一个关键优势 是与家庭和诊所工作的人员的连续性。

DESCRIPTION (provided by the applicant): Core A will serve as a resource for all projects and cores. Its principal objective is to recruit and re-examine 950 members of our original cohort of participants in the San Antonio Family Heart Study. The examination will take place in the Frederick C. Bartter General Clinical Research Center which is located at the Audie Murphy Memorial Veterans Hospital in San Antonio. The clinic examination will consist of four elements: verification and consent; an interview detailing medical and reproductive history, medications and vitamin usage, and lifestyle behaviors; physical measurements (heart rate, blood pressure, and various assessments of adiposity); and phlebotomy. The data and blood samples will be transported to Southwest Foundation for Biomedical Research where Core A personnel will: edit blood samples; conduct biochemical measurements of glucose, insulin, cholesterol and triglyceride concentrations and lipoprotein size phenotypes; and check all data for plausibility and consistency before making the data files available to program investigators. (End of abstract) The Clinical Core led by Dr. Rainwater has primary responsibility for the collection of data and samples, processing and storage of samples, the measurement of a large number of phenotypes from the blood samples and data entry and validation. A total of 809 individuals were seen during the current program project; 950 individuals will be brought back during the first four years of SAFHS3. The examinations will take place in the GCRC in the Audie Murphy Memorial Veterans Hospital and all supplies for the examination will be provided by the GCRC. Core A staff will be responsible for data management and sample handling. The investigators have shown that they are capable of getting good participation from family members in the follow-up study and will make extra efforts to follow key pedigree members. A similar battery of questionnaires and measurements will be used as was used in the previous study. The investigators have decided not to follow-up on family information in the interest of time. It might be worthwhile to at least assess vital status and health status of individuals who are not returning. It is also a shame that carotid artery measurements cannot be obtained again for a longitudinal study, especially since the initial heritabilities were so strong however this would likely be very costly and time consuming. This core is vital to the success of the project as a whole as new samples are required for the endocrinological function of adipose tissue and change in phenotypes in project 1 and the oxidative stress phenotypes in project 2. The general protocols for sample handling, sample storage, lipoprotein analysis and quality control are excellent. More information is needed on protocols for handling samples for the new phenotypes to be measured and how transfer of samples to outside laboratories and return of information will be accomplished. A key strength of this core is the continuity of personnel working with the families and in the clinic.