ABCA1 _ an Intersection between Infection, Atherosclerosis and Metabolic Disorders
ABCA1 _ an Intersection between Infection, Atherosclerosis and Metabolic Disorders
批准号:
nhmrc : 1019847
负责人:
A/Pr Barry Slobedman
金额:
$43.6万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2014-12-31
中文摘要
病原体干扰细胞胆固醇代谢,以支持其生命周期。这种干扰可能导致通常与感染无关的疾病,如心血管疾病。恢复正常的胆固醇代谢可能有助于治疗感染及其代谢后果。我们将研究病原体与胆固醇代谢相互作用的分子,细胞和生理机制,以找到一个可以靶向治疗干预的关键点。
英文摘要
Pathogens interfere with cellular cholesterol metabolism in order to support their lifecycle. Such interference may cause diseases not usually associated with infection, like cardiovascular disease. Restoring normal cholesterol metabolism may help treating infection and its metabolic consequences. We will investigate molecular, cellular and physiological mechanisms of interaction of pathogens with cholesterol metabolism to find a key point that can be targeted for therapeutic intervention.
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