TRAINING PROGRAM IN QUANTITATIVE BIOLOGY AND PHYSIOLOGY

超出所提供的空间。需要培养能够从定量、综合（跨越生物长度尺度）和系统的角度识别和处理生物学和生理学问题的研究人员。本提案旨在通过建立一个跨学科的博士前培训计划来满足这一需求，该计划将被安置在生物医学工程（BME）的系统和综合生物学领域。我们的定量生物学和生理学培训计划将培养同时了解分子生物学，细胞生物学和生理学的生物医学科学家，并具有强大的技术背景，从定量的角度研究生物学和生理学问题。我们将强调定量和数学建模技术，这些技术是机械的、基于结构的，通常在生物尺度上无处不在。我们的毕业生将获得在生物或生理系统或过程的各个层面（分子，细胞组织，器官，复杂生物动力学）分支所必需的技能，广度和经验。我们的项目提供了一个特殊的机会来联合波士顿大学的三个系：生物医学工程、生物学和数学；4个跨学科研究中心；以及分子生物学、细胞生物学和生物化学（MCBB）的跨学科项目。我们将为培训计划建立一个课程，包括严格的课程和实验室轮转接触：(a)定量分子生物学，细胞生物学和生理学，以及(b)四个主题领域的基于工程的生物学：分子生物学和基因工程，细胞和组织生物力学和电生理学，器官和感觉系统，以及复杂生物动力学。我们将要求学员进行跨学科、综合性、定量和与实验数据相关的论文研究。最后，我们将通过几个互动组件为参与我们计划的定量系统生物医学科学家建立一个独特的身份，包括定量生物学和生理学系列研讨会，学生-教师科学课程静修，每月晚宴和期刊俱乐部。总之，我们的目的是培养综合的、定量的、系统导向的生物医学科学家，他们将在学术机构（如大学和教学医院）和行业的生命科学界担任领导职务。网站性能 ======================================== 节结束 ===========================================

EXCEED THE SPACE PROVIDED. There is a need to develop researchers who can identity and approach problems in biology and physiology trom a quantitative, integrative (across biological length scales), and systems perspective. This proposal aims to fill this need by establishing an interdisciplinary Pre-doctoral training program addressing the Systems and Integrative Biology area that will be housed in biomedicalengineering (BME). Our TrainingProgram in Quantitative Biology and Physiology will produce biomedical scientists who understand molecularbiology, cell biology andphysiology simultaneously with a strong technical background to approach biological and physiological problems from a quantitative perspective. We will emphasize quantitative and mathematical modeling techniques that are mechanistic, structurally based, and often ubiquitous across biological scale. Our graduates will acquire the requisite skills, breadth, and experience to branch at all levels (molecular, cell-tissue, organ, complex biodynamics) of a biological or physiological system or process. Our program represents a special opportunity to unite three departments at Boston University: Biomedical Engineering, Biology, and Mathematics; four interdisciplinary research centers; and an interdisciplinary program in MolecularBiology, Cell Biology, and Biochemistry (MCBB). We will establish a curriculum for the trainingprogram that includes rigorous course and lab rotational exposure to: (a) quantitative molecular biology, cell biology, and physiology, and (b) engineering-based biology in four thematic areas: Molecular Biological and Genetic Engineering, Cellular and Tissue Biomechanics and Electrophysiology, Organ and Sensory Systems, and Complex Biodynamics. We will require trainees to conduct thesis research that is interdisciplinary, integrative, quantitative,and linked to experimental data. Finally, we will establish a unique identity for the Quantitative Systems Biomedical Scientists that participate in our program through several interactive components, including a Seminar Series in Quantitative Biology and Physiology, Student-Faculty Science-Curriculum Retreats, Monthly Dinners and Journal Clubs. In summary, our intent is to produce integrated, quantitative, and systems oriented biomedical scientists that will assume leadership positions in the life science communities of academic institutions (e.g., universities and teaching hospitals) and industry. PERFORMANCE SITE ========================================Section End===========================================