Training Program in Cellular and Molecular Medicine

描述（由申请人提供）：细胞和分子医学研究生课程（CMM）创建于1993年，提供。在对直接临床相关问题进行实验室研究的同时，为高素质博士候选人提供学习现代细胞和分子生物学理论和实践的机会。CMM是约翰霍普金斯医学院的一个独立的研究生项目，有单独的招生，一个特殊的课程，并被认证授予哲学博士学位（PhD）。今年是CMM开办的第10个年头，每年从175名申请者中选拔出15-20名新生，学生人数稳定在80-90人。截至2004年5月20日，共有42名学生从该项目毕业，该项目的规模在过去五年中几乎翻了一番。师资队伍来自临床科室（81人）和基础科学科室（25人）。他们被选中是因为他们成功的独立实验室项目，NIH的资助，以及他们适合担任年轻科学家的导师。重要的是，这些教员从事人类疾病的细胞和分子水平的研究，包括：癌症；心肺和血管疾病；神经生物学和神经疾病；免疫和传染病；代谢、发育和遗传缺陷。第一年的课程提供严格的讲授课程，包括人体生物学（“人体概论”）、疾病的细胞和分子基础以及基础科学：分子生物学和基因组学；通路和调控；细胞结构与动力学；遗传学基础；人类遗传学和免疫学。一年级学生还将参加CMM教师的小组讨论，参加细胞和分子医学专题研讨会，并参加由CMM高年级荣誉学生提供的教程。一年级学生在选择论文实验室之前，在CMM教师实验室进行三次研究轮转。第二年的学生在秋季参加口头研究生委员会考试，并完成两门额外的必修课程：药理学，以及病毒学或生物化学和生物物理原理的选择。在接下来的几年里，学生们选修四门课程，参加由CMM项目和论文部门提供的研讨会和期刊俱乐部。CMM的目标是培养年轻科学家在细胞和分子水平上研究人类疾病。我们预计，大多数CMM毕业生将在医学院担任学术职位，在临床部门进行研究，而一些人可能会选择在工业领域进行研究。演出地点(S)（组织，城市，州）约翰霍普金斯大学医学院725 N. Wolfe街巴尔的摩，马里兰州21205主要人员。看到指令。根据需要使用延续页，以下列格式提供所需的信息。从首席调查员开始。按字母顺序列出所有其他重要人员，姓氏在前。项目组织角色：Pierre教授主任Agre， Peter教授顾问/顾问委员会Alani， Rhoda助理教授讲师/导师Ambinder， Richard教授讲师/导师Baraban， Jay教授顾问/委员会成员Baylin， Stephen教授顾问委员会/顾问Bhujwalla， Zaver教授导师Bishai， William副教授顾问/讲师Bulkley， David副教授导师Bulkley， Gregory教授导师Burnett，亚瑟教授导师披露许可声明。仅适用于SBIR/STTR。看到指令。^是C] No PHS 398 (Rev. 05/01) ' Page 2

DESCRIPTION (provided by applicant): The Graduate Program in Cellular and Molecular Medicine (CMM) was created in 1993 and offers .highly qualified Ph.D. candidates the opportunity to learn the theory and practice of modern cellular and molecular biology while conducting laboratory research on problems with direct clinical relevance. CMM is an independent Graduate Program at the Johns Hopkins School of Medicine with separate admissions, a special curriculum, and is certified to award the degree of Doctor of Philosophy (PhD). Now in its tenth year, CMM matriculates -15-20 incoming students selected from -175 applicants every year, producing a steady state of -80-90 students. A total of 42 students (as of May 20, 2004) have graduated from the Program, which has nearly doubled in size over the past five years. CMM faculty members are from clinical departments (81 individuals) and basic science departments (25 individuals). They were selected because of their successful independent laboratory programs, NIH funding, and their suitability to serve as mentors for young scientists. Importantly, these faculty members pursue research at cellular and molecular levels on human diseases including: cancer; cardiopulmonary and vascular disorders; neurobiology and neurological disorders; immunological and infectious diseases; metabolic, developmental, and genetic defects. The first year curriculum provides rigorous lecture courses in human biology ("Introduction to the Human Body"), the Cellular and Molecular Basis of Disease, and basic sciences: Molecular Biology and Genomics; Pathways and Regulation; Cell Structure and Dynamics; Fundamentals of Genetics; Human Genetics, and Immunology. First year students also participate in small group discussions with CMM faculty, attend Topics in Cellular and Molecular Medicine Seminars, and partake in a tutorial presented by upper-class CMM honors students. First year students perform three research rotations in CMM faculty laboratories before selecting a thesis laboratory. Second year students take the oral graduate board examination in the fall period, and complete two additional required courses: Pharmacology, and a choice of either Virology or Biochemical and Biophysical Principles. In subsequent years, students take four elective courses and attend seminars and journal clubs offered by the CMM Program as well as in their thesis departments. The goal of CMM is to train young scientists for careers studying human diseases at cellular and molecular levels. We expect that most CMM graduates will take academic positions in medical schools pursuing research in clinical departments, while some may choose to pursue research in industry. PERFORMANCE SITE(S) (organization, city, state) Johns Hopkins University School of Medicine 725 N. Wolfe Street Baltimore, MD 21205 KEY PERSONNEL. See instructions. Use continuation pages as needed to provide the required information in the format shown below. Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name Organization Role on Project Coulombe, Pierre Professor Director Agre, Peter Professor Advisor/Advisory Board Alani, Rhoda Assistant Professor Lecturer/Preceptor Ambinder, Richard Professor Lecturer/Preceptor Baraban, Jay Professor Advisor/Committee Member Baylin, Stephen Professor Advisory Board/Advisor Bhujwalla, Zaver Professor Preceptor Bishai, William Associate Professor Advisor/Lecturer Borchelt, David Associate Professor Preceptor Bulkley, Gregory Professor Preceptor Burnett, Arthur Professor Preceptor Disclosure Permission Statement. Applicable to SBIR/STTR Only. See instructions. ^ Yes C] No PHS 398 (Rev. 05/01) ' Page 2