Training Program in Cellular and Molecular Medicine

描述(由申请人提供)：细胞和分子医学研究生项目(CMM)创建于1993年，为高素质的博士候选人提供了学习现代细胞和分子生物学理论和实践的机会，同时对与临床直接相关的问题进行实验室研究。CMM是约翰·霍普金斯医学院的一个独立研究生项目，有单独招生的特殊课程，并被认证为授予哲学博士学位(PhD)。现在已经是第十个年头了，CMM每年从175名申请者中挑选15-20名入学学生，稳定在-80-90名学生的状态。截至2004年5月20日，共有42名学生从该项目毕业，该项目的规模在过去五年中几乎翻了一番。CMM的教职员工来自临床科室(81人)和基础科学系(25人)。他们被选中是因为他们成功的独立实验室项目，NIH的资助，以及他们适合作为年轻科学家的导师。重要的是，这些教员致力于人类疾病的细胞和分子水平的研究，包括：癌症；心肺和血管疾病；神经生物学和神经疾病；免疫和传染病；代谢、发育和遗传缺陷。第一年的课程提供严格的人类生物学(“人体概论”)，疾病的细胞和分子基础，以及基础科学：分子生物学和基因组学；途径和调控；细胞结构和动力学；遗传学基础；人类遗传学和免疫学。一年级学生还参加与CMM教师的小组讨论，参加细胞和分子医学研讨会的主题，并参加由高年级CMM荣誉学生提供的教程。一年级学生在选择论文实验室之前，在CMM学院实验室进行三次研究轮换。二年级的学生在秋季参加口试，并完成两门额外的必修课程：药理学，以及选择病毒学或生化和生物物理原理。在接下来的几年里，学生们要选修四门课程，参加CMM项目提供的研讨会和期刊俱乐部，以及在他们的论文部门。CMM的目标是为在细胞和分子水平上研究人类疾病的职业培养年轻的科学家。我们预计，大多数CMM毕业生将在医学院担任学术职位，在临床科从事研究，而一些人可能会选择在工业领域进行研究。演出现场(S)(组织、市、州)约翰霍普金斯大学医学院725N沃尔夫大街，马里兰州巴尔的摩21205名关键人员。请参阅说明。根据需要使用续页，以如下所示的格式提供所需信息。从首席调查员开始。按字母顺序列出所有其他关键人员，姓氏在前。名称组织在库伦贝项目中的作用，Pierre教授主任Agre，Peter教授顾问/顾问委员会Alani，罗达助理教授讲师/P受体Ambinder，理查德教授讲师/P受体Baraban，Jay教授顾问/委员会成员Baylin，Stephen教授顾问/顾问布杰瓦拉，Zaver教授P受体顾问/顾问Bishai，威廉副教授顾问/讲师Borchelt，David副教授P受体Bulkley，Gregory教授P受体Burnett，Arthur教授P受体披露许可声明。仅适用于SBIR/STTR。请参阅说明。^是C]No PHS 398(05/01版)‘第2页

DESCRIPTION (provided by applicant): The Graduate Program in Cellular and Molecular Medicine (CMM) was created in 1993 and offers .highly qualified Ph.D. candidates the opportunity to learn the theory and practice of modern cellular and molecular biology while conducting laboratory research on problems with direct clinical relevance. CMM is an independent Graduate Program at the Johns Hopkins School of Medicine with separate admissions, a special curriculum, and is certified to award the degree of Doctor of Philosophy (PhD). Now in its tenth year, CMM matriculates -15-20 incoming students selected from -175 applicants every year, producing a steady state of -80-90 students. A total of 42 students (as of May 20, 2004) have graduated from the Program, which has nearly doubled in size over the past five years. CMM faculty members are from clinical departments (81 individuals) and basic science departments (25 individuals). They were selected because of their successful independent laboratory programs, NIH funding, and their suitability to serve as mentors for young scientists. Importantly, these faculty members pursue research at cellular and molecular levels on human diseases including: cancer; cardiopulmonary and vascular disorders; neurobiology and neurological disorders; immunological and infectious diseases; metabolic, developmental, and genetic defects. The first year curriculum provides rigorous lecture courses in human biology ("Introduction to the Human Body"), the Cellular and Molecular Basis of Disease, and basic sciences: Molecular Biology and Genomics; Pathways and Regulation; Cell Structure and Dynamics; Fundamentals of Genetics; Human Genetics, and Immunology. First year students also participate in small group discussions with CMM faculty, attend Topics in Cellular and Molecular Medicine Seminars, and partake in a tutorial presented by upper-class CMM honors students. First year students perform three research rotations in CMM faculty laboratories before selecting a thesis laboratory. Second year students take the oral graduate board examination in the fall period, and complete two additional required courses: Pharmacology, and a choice of either Virology or Biochemical and Biophysical Principles. In subsequent years, students take four elective courses and attend seminars and journal clubs offered by the CMM Program as well as in their thesis departments. The goal of CMM is to train young scientists for careers studying human diseases at cellular and molecular levels. We expect that most CMM graduates will take academic positions in medical schools pursuing research in clinical departments, while some may choose to pursue research in industry. PERFORMANCE SITE(S) (organization, city, state) Johns Hopkins University School of Medicine 725 N. Wolfe Street Baltimore, MD 21205 KEY PERSONNEL. See instructions. Use continuation pages as needed to provide the required information in the format shown below. Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name Organization Role on Project Coulombe, Pierre Professor Director Agre, Peter Professor Advisor/Advisory Board Alani, Rhoda Assistant Professor Lecturer/Preceptor Ambinder, Richard Professor Lecturer/Preceptor Baraban, Jay Professor Advisor/Committee Member Baylin, Stephen Professor Advisory Board/Advisor Bhujwalla, Zaver Professor Preceptor Bishai, William Associate Professor Advisor/Lecturer Borchelt, David Associate Professor Preceptor Bulkley, Gregory Professor Preceptor Burnett, Arthur Professor Preceptor Disclosure Permission Statement. Applicable to SBIR/STTR Only. See instructions. ^ Yes C] No PHS 398 (Rev. 05/01) ' Page 2