Cancer Biology Training Program

简介（由申请人提供）：埃普利研究所是内布拉斯加州大学医学中心（UNMC）的一个学术单位，其唯一的重点是基础癌症研究。它是nci指定的UNMC埃普利癌症中心的主要组成部分。UNMC拥有两个nci指定的癌症中心之一，在6个州的中心地带，有超过125名教职员工参与实验室和临床研究。因此，Eppley研究所和癌症研究培训计划（CRTP）在培养未来的基础和临床科学家方面发挥着重要的区域作用。我们从全国范围内招募博士生和博士后。NCI培训补助金支持CRTP的一个关键部分，目前有26名博士前研究员和42名博士后在培训。CRTP的教职员工在基础广泛的癌症研究培训项目中具有广泛的专业知识，包括生物化学、细胞和结构生物学、药物传递、遗传学、免疫学、有机和药物化学、病理药剂学和药效学、药理学和临床肿瘤学。埃普利研究所的CRTP不授予博士学位，所有进入CRTP的研究生都有机会在CRTP的教员中轮岗，然后在参与的院系中选择一名论文指导老师：生物化学和分子生物学、病理学和微生物学、制药科学和药理学。我们的一些学员直接参与了转化研究活动，如白血病的基因靶向治疗、儿茶酚类雌激素在人类乳腺癌中的作用、放射免疫结合治疗和肿瘤疫苗的开发、妇科癌症肿瘤标志物的开发。培训基金的目标是为每位博士生和博士后提供知识基础、实验室技能和解决问题的能力，使他们成为独立、创新的癌症研究人员。CRTP的具体目标是为博士后和博士后提供：(1)关于致癌机制、人类癌症流行病学和癌症预防潜力的知识；(2)在基础科学（生物化学和分子生物学、遗传学、免疫学、病理学、制药科学、药理学）领域有深入的背景，这是研究和理解正常细胞转化为癌细胞以及设计诊断和治疗方法所必需的；(3)运用这些信息规划和开展癌症病因、预防、诊断和治疗方面的创新研究的能力；(4)认识到跨学科研究的力量。为了实现这些目标，CRTP必须能够吸引高素质和积极进取的研究生和博士后，并为他们提供高质量的教学和实验室经验。

DESCRIPTION (provided by applicant): The Eppley Institute is an academic unit of the University of Nebraska Medical Center (UNMC) with its sole focus on basic cancer research. It is a major component of the NCI-designated UNMC Eppley Cancer Center. UNMC has one of two NCI-designated Cancer Centers in a 6 state region of the heartland and has more than 125 faculty members involved in laboratory and clinical research. As such, the Eppley Institute and the Cancer Research Training Program (CRTP) play an important regional role in training future basic and clinical scientists. We recruit from a national pool of predoctoral and postdoctoral fellows. The NCI Training Grant supports a key part of the CRTP, which currently has 26 predoctoral and 42 postdoctoral fellows in training. The CRTP faculty have a wide variety of expertise in areas important for a broad-based cancer research training program, including biochemistry, cellular and structural biology, drug delivery, genetics, immunology, organic and medicinal chemistry, pathology pharmaceutics and pharmacodynamics, pharmacology, and clinical oncology. The Eppley Institute's CRTP does not grant a doctoral degree, and all entering graduate students have a chance to rotate with CRTP faculty before they pick a thesis advisor in one of the participating departments: Biochemistry and Molecular Biology, Pathology and Microbiology, Pharmaceutical Sciences, and Pharmacology. A number of our trainees are directly involved in translational research activities, e.g., gene-targeted therapy for leukemia, role of catechol estrogens in human breast cancer, radioimmunoconjugate therapy and tumor vaccine development, development of tumor markers for gynecologic cancer. The goal of the training grant is to provide each doctoral student and postdoctoral fellow with the knowledge base, laboratory skills, and problem solving abilities to become independent, innovative cancer investigators. The specific aims of the CRTP are to provide pre- and postdoctoral trainees with: (1) knowledge of the mechanisms of carcinogenesis, the epidemiology of human cancer, and the potential for cancer prevention; (2) an in-depth background in the areas of basic science (biochemistry and molecular biology, genetics, immunology, pathology, pharmaceutical sciences, pharmacology) that is necessary to study and understand the conversion of normal cells to cancer cells and to design methods of diagnosis and treatment; (3) the ability to apply this information to plan and conduct innovative research on the causes, prevention, diagnosis and treatment of cancer; and (4) an appreciation of the power of interdisciplinary research. To achieve these aims the CRTP must be able to attract highly qualified and motivated graduate students and postdoctoral fellows and provide them with high quality didactic and laboratory experiences.