Spatiotemporal Dynamics of Emotional Memory Networks

描述：(申请人提供) 对情绪插曲的记忆与我们的 自传式体验，但对大脑机制知之甚少 参与在记忆中编码和保留情感事件。建议数 研究使用现代认知神经科学技术来揭示对 大规模大脑网络的组织将情感刺激与 长期记忆功能。为了实现这一目标，心理生理学， 事件相关电位(ERP)和功能磁共振成像(FMRI) 方法将用来调查情绪对神经生理学的影响 正常人记忆编码和提取任务中的线索。新的 将应用技术来改善额叶边缘脑的fMRI信号 并推断其激活的时间进程。空间和时间 通过平行的ERP和功能磁共振研究获得的信息将合并到 指定边缘前脑区域对情绪突显的敏感程度 操作与专用于 助记和知觉过程。据推测，腹内侧 前额叶皮质和杏仁核将调节感觉联系的活动 大脑皮层对刺激的反应。因此，情感事件将 接收增强的刺激绑定并促进从记忆相关的检索 内侧颞叶和前额叶皮质的区域。情态 将询问情绪网络组件的特殊性，并且 大脑的激活模式将与外周的变化相关 个别受试者的自主神经生理学和记忆力得分。 在吸毒成瘾人群中，对以前吸毒和吸毒的情景记忆 药物相关环境线索引发的助记联想起到了 在成瘾过程中的激励方面的重要作用和贡献 药物耐受性背后的生理适应。建议进行的研究 可能通过提供更多的 准确而详细地描述了情绪和情绪之间的动态相互作用 人类大脑中的记忆系统。

DESCRIPTION: (provided by applicant) Memories for emotional episodes are intricately associated with our autobiographical experience, yet little is known about the brain mechanisms involved in encoding and retaining emotional events in memory. The proposed research uses modern cognitive neuroscience techniques to reveal insights into the organization of large-scale brain networks that link emotional stimuli to long-term memory functions. To achieve this aim, psychophysiological, event-related potential (ERP), and functional magnetic resonance imaging (fMRI) methods will be used to investigate the neurophysiological impact of emotional cues during memory encoding and retrieval tasks in normal human subjects. New techniques will be applied to improve the fMRI signal in frontolimbic brain areas and to infer their time course of activation. The spatial and temporal information obtained across parallel ERP and fMRI studies will be combined to specify how limbic forebrain areas sensitive to emotional salience manipulations dynamically interact with cortical networks specialized for mnemonic and perceptual processes. It is hypothesized that the ventromedial prefrontal cortex and amygdala will modulate activity in sensory association cortex in response to arousing stimuli. As a result, emotional events will receive enhanced stimulus binding and facilitated retrieval from memory-related areas in the medial temporal lobe and prefrontal cortex. The modality specificity of the emotional network components will be interrogated, and the brain activation patterns will be correlated with peripheral changes in autonomic physiology and memory scores in individual subjects. In drug addiction populations, episodic memories for prior drug intake and mnemonic associations triggered by drug-related environmental cues play an important role in motivational aspects of the addictive process and contribute to physiological adaptations underlying drug tolerance. The proposed studies may lead to new insights into understanding these effects by providing a more accurate and detailed account of the dynamic interplay between emotion and memory systems in the human brain.