Emotional modulation of implicit and explicit memory systems

对情感事件的记忆构成了我们个人历史的核心，但人们对情感事件的记忆却知之甚少。 调节情绪对人脑记忆影响的神经认知机制。的 一项拟议的研究使用现代认知神经科学技术来阐明情绪处理是如何 神经网络与记忆系统和执行控制区域接口，以增强显式（声明性） 和人类记忆的内隐（非陈述）形式。为了实现这一目标， 健康成人的磁共振成像研究将结合行为和颅内 事件相关电位研究癫痫患者在记忆编码任务中的刺激， 情绪凸显我们假设外显记忆中的情绪保持优势取决于 杏仁核和内侧颞叶记忆系统（MMS）之间的相互作用， 根据执行功能，还将涉及纹外、顶叶和前额叶皮层（RFC）区域 与知觉/注意力、工作记忆和语义处理有关。我们进一步预测， 内隐记忆的保持优势，如知觉启动所测量的，取决于交互作用 杏仁核和感觉新皮层之间的联系最后，我们预计， 有意识地调节情绪对外显记忆的影响大于内隐记忆， 是通过前额叶皮层和前扣带回的认知控制区对大脑皮层活动的影响来实现的。 杏仁核和MMS作为一个功能的有效性和类型的监管策略部署。 这项研究对于理解癫痫如何影响大脑具有特定的临床意义 形成情感体验记忆的结构，以及癫痫患者可以在多大程度上使用 认知策略来改变他们的情感记忆这项研究与公共卫生的相关性更大 它可以帮助理解情感记忆是如何在各种各样的情况下变得功能失调的。 神经系统疾病通过提供详细的 人类情感、记忆和执行控制系统之间的动态相互作用 个脑袋

Memories for emotional events constitute the core of our personal history, yet little is known about the neurocognitive mechanisms that mediate the influence of emotion on memory in the human brain. The proposed research uses modern cognitive neuroscience techniques to elucidate how emotion processing networks interface with memory systems and executive control regions to enhance both explicit (declarative) and implicit (non-declarative) forms of human memory. To achieve this aim, behavioral and functional magnetic resonance imaging studies of healthy adults will be combined with behavioral and intracranial event-related potential studies of epileptic patients during memory encoding tasks for stimuli that vary in their emotional salience. We hypothesize that emotional retention advantages in explicit memory depend on interactions between the amygdala and medial temporal lobe memory system (MMS), and that these effects will also involve extrastriate, parietal, and prefrontal cortex (RFC) regions according to executive functions related to perception/attention, working memory, and semantic processing. We further predict that emotional retention advantages in implicit memory, as measured by perceptual priming, depend on interactions between the amygdala and sensory neocortex in a modality-specific manner. Finally, we expect that conscious attempts to regulate one's emotions have a greater impact on explicit than implicit memory and are implemented by influences of cognitive control regions of the PFC and anterior cingulate on activity in the amygdala and MMS as a function of the effectiveness and type of regulation strategy deployed. The proposed research has specific clinical implications for understanding how epilepsy affects brain structures that form memories for emotional experiences, and the extent to which epileptic patients can use cognitive strategies to alter their emotional memories. This research has relevance for public health more broadly in that it can help understand how emotional memories become dysfunctional in a variety of neurologic disorders. New insights into these clinical conditions will be gained by providing a detailed account of the dynamic interplay between emotion, memory, and executive control systems in the human brain.