Emotional modulation of implicit and explicit memory systems

内隐和外显记忆系统的情绪调节

• 批准号: 7156142
• 负责人: KEVIN S LABAR
• 金额: $ 14.08万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7156142
• 关键词: emotions; memory

Memories for emotional events constitute the core of our personal history, yet little is known about the neurocognitive mechanisms that mediate the influence of emotion on memory in the human brain. The proposed research uses modern cognitive neuroscience techniques to elucidate how emotion processing networks interface with memory systems and executive control regions to enhance both explicit (declarative) and implicit (non-declarative) forms of human memory. To achieve this aim, behavioral and functional magnetic resonance imaging studies of healthy adults will be combined with behavioral and intracranial event-related potential studies of epileptic patients during memory encoding tasks for stimuli that vary in their emotional salience. We hypothesize that emotional retention advantages in explicit memory depend on interactions between the amygdala and medial temporal lobe memory system (MMS), and that these effects will also involve extrastriate, parietal, and prefrontal cortex (RFC) regions according to executive functions related to perception/attention, working memory, and semantic processing. We further predict that emotional retention advantages in implicit memory, as measured by perceptual priming, depend on interactions between the amygdala and sensory neocortex in a modality-specific manner. Finally, we expect that conscious attempts to regulate one's emotions have a greater impact on explicit than implicit memory and are implemented by influences of cognitive control regions of the PFC and anterior cingulate on activity in the amygdala and MMS as a function of the effectiveness and type of regulation strategy deployed. The proposed research has specific clinical implications for understanding how epilepsy affects brain structures that form memories for emotional experiences, and the extent to which epileptic patients can use cognitive strategies to alter their emotional memories. This research has relevance for public health more broadly in that it can help understand how emotional memories become dysfunctional in a variety of neurologic disorders. New insights into these clinical conditions will be gained by providing a detailed account of the dynamic interplay between emotion, memory, and executive control systems in the human brain.

对情感事件的记忆构成了我们个人历史的核心，但人们对 调节情绪对人脑记忆影响的神经认知机制。这个 拟议的研究使用现代认知神经科学技术来解释情绪如何处理 网络与存储系统和执行控制区域对接，以增强显性(声明性) 以及人类记忆的内隐(非陈述性)形式。为了实现这一目标，行为和功能 健康成年人的磁共振成像研究将结合行为和颅内 癫痫患者对不同刺激的记忆编码任务的事件相关电位研究 情绪上的突显。我们假设情绪保持在外显记忆中的优势依赖于 杏仁核和内侧颞叶记忆系统(MMS)之间的相互作用，以及这些效应 还将根据执行功能涉及纹外、顶叶和前额叶皮质(RFC)区域 与知觉/注意、工作记忆和语义加工有关。我们进一步预测，情绪 通过知觉启动测量的内隐记忆中的保持优势取决于交互作用 杏仁核和感觉新皮质之间以一种特定的方式。最后，我们期待着 有意识地试图调节情绪对外显记忆的影响比内隐记忆更大 是通过PFC和前扣带回的认知控制区对脑电活动的影响来实现的。 杏仁核和MMS作为一种功能调节策略部署的有效性和类型。 这项拟议的研究对于了解癫痫对大脑的影响具有特定的临床意义。 形成情感体验记忆的结构，以及癫痫患者可以使用的程度 认知策略来改变他们的情感记忆。这项研究对公共卫生更具相关性 广义地说，它可以帮助理解情绪记忆是如何在各种不同的 神经紊乱。对这些临床情况的新见解将通过提供详细的 描述人类情绪、记忆和执行控制系统之间的动态相互作用 大脑。