Motivated Learning and Memory Neuroimaging Data Repository

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Brain imaging is an emerging neuroscientific tool that has become central to characterizing the pathophysiology of drug addiction. Structural and functional brain imaging studies have contributed to an understanding of the component neural systems and cognitive processes that mediate maladaptive drugseeking, risky choice, and avoidant behaviors, including those related to learning and memory. Due to the rapid pace of imaging research, the cost of the studies, the need to increase statistical power, and the complexity of the data collected, it is vital to share existing neuroimaging data sets with other researchers to facilitate scientific discovery into the causes and consequences of drug-related behaviors. This proposal is a one-year administrative supplement to a NIDA-funded R01 grant to establish a public data repository on brain imaging studies related to motivated learning and memory (LAM). Structural and functional imaging data collected as part of the parent grant will be shared and linked to another public repository of resting state data in addictive disorders (RAD). Some unique features of the data to be shared include the focus on LAM processes, high-resolution functional imaging of medial temporal, striatal, and frontal regions involved in drug addiction, and a core set of reward and punishment-related tasks and manipulations suitable for meta-analysis. Intellectual property rights and other regulations for data access and publication will be developed, and database linking structures will be created. While early attempts to establish large, monolithic brain imaging data repositories failed due to problems of scale and maintenance, we envision an alternate approach of linked ¿niche¿ databases whose organization is inspired by brain architecture and social networks.