Total synthesis of Zoanthamine

18. 我培训的主要目标是学习必要的技能，成为一名优秀的有机化学家，能够在大学水平上教授有机化学，并能独立进行研究。Theodorakis的实验室培育新思想，鼓励有机合成新方法的发展。这种方法将增强我对化学反应性的理解。在Theodorakis小组每周的研究会议上，每个学生都会对他们正在进行的研究进行彻底的解释，这有助于我练习我的教学技巧，并更好地理解化学。此外，有机化学与生物学之间的相关性也不断被讨论，以便更好地了解不同分子的生物作用方式。这个项目将使我接触到尽可能多的化学知识，以便在实验室和课堂上取得成功。这项奖学金将使我实现我的职业目标，即完成博士学位，最终在大学任教，并为弱势少数群体树立榜样。姓名和学位(S) Emmanuel Theodorakis， 20岁。位置/排名加州大学圣何塞分校研究方向：天然产物全合成与药物设计描述（不超过空格）赞助商有机化学博士学位Diego有机化学教授i| _tl _；我们的目标是开发一种可行的合成方法，以简洁的方式生产出甲氰胺和该生物碱家族的其他成员，如去甲氰胺。这些生物碱大多具有高度功能化的反式癸酮和杂环胺环体系，并至少具有三个季手性中心（杂蒽醌为C-9， C-12, C-22）。在一个模型系统中，发现Zoanthamine及其近缘物具有抑制肉豆酸酯佛波引起的炎症的作用。诺佐那敏抑制P388小鼠白血病细胞的生长。此外，去甲氰胺抑制IL-6的产生。最近，有报道称，黄花胺类生物碱抑制骨量的下降。zooanthamine核心的构建将引导我们有希望建立一个类似物库，以进一步研究它们作为骨质疏松药物和/或抗炎药物的候选药物的潜力。PHS 416-1 （Rev. 12/98）表格第2页BB co NAME（最后，第一，中间首字母）个人NRSA应用程序Rivas， Fatima， R目录页编号（在整个应用程序的底部连续编号页）。请参阅第i节申请人附录5a， 5b。脸(项目1 - 8、15页),表单页面2(项目16 - 22),和表的内容 ======================================== 节结束 ===========================================

18. GOALS FOR FELLOWSHIP TRAINING AND CAREER The primary goal for my training is to learn the necessary skills to become an excellent organic chemist who can teach organic chemistry at the university level and can conduct research independently. The Theodorakis' laboratory nurtures new ideas and encourages the development of new methodologies in organic synthesis. This approach will enhance my understanding chemical reactivity. The weekly research meetings of the Theodorakis' group during which every student presents a thorough explanation of their ongoing research will help me practice my teaching skills and to develop a better understanding of chemistry. In addition, the correlation between organic chemistry and biology is constantly discussed in order to better understand the biological mode of action of different molecules. This project will expose me to as much chemistry as needed to succeed in the laboratory as well as in the classroom. This fellowship would enable me to accomplish my career goals which are to complete my Ph. D to ultimately teach at the university level and set a role model to disadvantaged minority groups 19. NAME AND DEGREE(S) Emmanuel Theodorakis, 20. POSITION/RANK University of California, San 21. RESEARCH INTERESTS/AREAS Total Synthcsis of Natural Products and Drug Design 22. DESCRIPTION (Do not exceed space provided) SPONSOR Doctorate degree in Organic Chemistry Diego Organic Chemistry Professor i| _tl _;1 ",'ol"n -,,-Il_o]llo]-'_'i_l Our goal is to develop a feasible synthetic procedure that can yield Zoanthamine and other members of this alkaloid family such as norzoanthamine in a concise manner. Most of these alkaloids possess highly functionalized trans-decalone and heterocyclic aminal ring system along with at least three quaternary chiral centers (C-9, C-12, C-22 for zoanthamine). Zoanthamine and its relatives were found to inhibit phorbol myristate acetate induced inflammation in a model system. Norzoanthamine was found to inhibit the growth of P388 murine leukemia cell cultures. In addition, norzoanthamine inhibits IL-6 production. Recently, it has been reported that zoanthamine-type alkaloids suppress the decrease in bone weight. The construction of the core of zoanthamine will lead us to hopefully develop a library of its analogs to further study their potential as candidates for an osteoporotic drug and/or an anti-inflammatory drug. PHS 416-1 (Rev. 12/98) Form Page 2 BB co NAME(Last, first,middle initial) Individual NRSA Application Rivas, Fatima, R Tabte of Contents Page Numbers (Numberpagesconsecutively at thebottomthroughouthe applicationD. onotuse Section I-Applicant suffixesuchas5a, 5b.) Face Page (Items 1-8, 15), Form Page 2 (items 16-18, 22), and Table of Contents ========================================Section End===========================================