Population Genetics Theory

将对遗传学进行研究。首先，我们将开发稳健的估计器 这个 是否有任何人口结构或历史记录。在应用于Y染色体或 线粒体DNA，允许重组的修饰将被引入 并对常染色体和X连锁序列进行了检验。方法是 第二 该项目研究蛋白质-蛋白质相互作用与 利用已发表的数据库计算酵母的进化率。我们会调查的 蛋白质之间的相互作用是否对进化有直接影响 它是否由适应度和进化之间的关系所调节 费率。在项目3中，我们研究了两种新的基因组印迹模型。这个 首先是我们之前确切的群体遗传的X连锁版本 治疗。第二种发展了一个三变量的数量遗传 结构，其中一个变量作为 家长。 复杂性。第一个研究控制基因的等位基因的命运。 其他基因之间的上位性互作水平。第二个扩展了我们的 遗传效应模型的生态位构建的理论工作 由人类行为引起的非人类物种，如使用抗生素， 都是通过文化传播的。第三个目的是研究连杆机构的动力学 影响不同文化传播的基因之间的不平衡 特征，以及在性选择中的应用。

DESCRIPTION (provided by applicant): Four areas of theoretical population genetics will be studied. In the first, we will develop robust estimators for the time to the most recent common ancestor in a sample of DNA sequences. The objective is to find an estimator that works well when the sampled population has any demographic structure or history. After application to Y-chromosomal or mitochondrial DNA, modifications to allow for recombination will be introduced and the estimator tested on autosomal and X-linked sequences. The method is designed to apply to most of the commonly studied DNA variants. The second project studies the relationship between protein-protein interactions and the rate of evolution in yeast using published databases. We will investigate whether the interaction between proteins has a direct effect on evolutionary rate or if it is mediated by the relationship between fitness and evolutionary rate. In Project 3, we investigate two new models of genomic imprinting. The first is an X-Iinked version of our previous exact population genetic treatment. The second develops a three-variable quantitative inheritance structure with one variable as the level of activation of growth factor by a parent. The final project is devoted to three versions of the evolution of complexity. The first studies the fate of alleles at a gene that controls the level of epistatic interaction between other genes. The second extends our theoretical work on niche construction to models for the genetic effects on non-human species caused by human behaviors, such as use of antibiotics, that are culturally transmitted. The third aims to study the dynamics of linkage disequilibrium between genes that affect different culturally transmitted traits, with an application to sexual selection.