Cross-Disciplinary Dental Science Research Training

描述(由申请人提供)： 这次研究培训补助金续签申请是对我们最初的提案的重新提交，该提案旨在支持华盛顿大学牙科学院的跨学科和全面的牙科研究培训。这项申请构成了以前的口腔生物学-唾液研究培训和细菌诱导的慢性炎症研究培训赠款的竞争性更新。修订后的申请包括一个单一的研究培训设施和计划，重点是使用分子和细胞生物学以及生物工程方法来研究口腔组织的基本生物学及其对微生物病原体和惰性材料的反应。该方案由一名方案协调员管理，并由方案监督委员会指导。合作培训学院包括来自牙医学院、医学院、公共卫生学院和生物工程系的个人；并根据研究兴趣被组织成12个小组。拟议的培训计划包括两个阶段：1)所有受训人员将接受PA中提到的主要能力领域的课程，包括：基因组学、分子生物学和分子流行病学、基因介导的诊断和治疗学、细胞生物学、生物信息学、生物材料、生物仿生学、纳米技术、组织工程和生物成像技术。课程还将包括实验设计和数据分析，以及牙科科学。博士生将接受最多的培训；MS和短期实习生将获得较少的培训。2)所有学员将学习使用分子和细胞生物学和/或生物工程方法进行生物实验，在从拟议的培训学院中挑选的研究导师的指导下设计和进行实验。本次征集培训岗位共12.75个，其中博士后岗位6个，博士后长期岗位5个，牙科专业学生短期岗位1.5个，口腔学校新、中期教师短期岗位0.25个。虽然长期受训学生可以选择在6个系攻读博士或硕士学位(仅限牙医)，但口腔生物学和生物工程的招生人数预计会最高。将对与此培训相结合的课程进行较为详细的描述。

DESCRIPTION (provided by applicant): This Research Training Grant renewal application is an extensively revised resubmission of our initial proposal to support cross-disciplinary and comprehensive dental science research training at the School of Dentistry at the University of Washington. The application constitutes the competing renewal of the former Oral Biology-Salivary Research Training and the Bacterially Induced Chronic Inflammation Research Training grants. The revised application consists of a single research training facility and program, focused on using molecular and cell biology and bioengineering approaches to study the basic biology of the oral tissues and their reactions to microbial pathogens and inert materials. The Program is administered by a Program Coordinator, and directed by a Program Oversight Committee. The collaborating Training Faculty include individuals from the Schools of Dentistry, Medicine, Public Health and the Department of Bioengineering; and are organized into 12 groups based on research interests. The proposed training program consists of two phases: 1) All trainees will receive coursework in the major competency areas cited in the PA including: genomics, molecular biology and molecular epidemiology, gene-mediated diagnosis and therapeutics, cell biology, bioinformatics, biomaterials, biomimetics, nanotechnology, tissue engineering and bioimaging technology. Coursework will also include experimental design and data analysis, and dental sciences. PhD students will receive the most training; MS and short-term trainees will receive less. 2) All trainees will learn to perform biological experiments using molecular and cell biology and/or bioengineering approaches by designing and performing experiments under the direction of a Research Mentor chosen from the proposed training faculty. A total of 12.75 training positions are requested, of which 6 are postdoctoral and 5 are predoctoral long term positions, 1.5 are short term positions for dental students, and 0.25 are short term positions for new and midcareer dental school faculty. Although long term trainees may elect to matriculate in a PhD or MS (dentists only) programs in 6 departments, Oral Biology and Bioengineering are expected to have highest enrollments. Courses to be taken in conjunction with this training are described in some detail.