SEARCH for Diabetes in Youth 2: Ohio Center

描述（由申请人提供）：该提案建立在一个为期五年的研究项目，青年糖尿病，其标准化的数据收集工作，经验丰富的研究人员团队，建立病例确定基础设施和种族多样化的人口基础之上。 这是一个来自六个临床研究中心的共同的综合申请，它建议继续和扩大由临床研究中心进行的工作，以解决以下具体的研究目标：目的1：（2006-2009年）年龄小于20岁的发病病例，以估计青年DM发病率的时间趋势：AIM 2：对2002年至2005年招募到糖尿病研究中心的新发病例进行纵向随访，以根据临床和生化因素记录新诊断的糖尿病的演变;完成了在医疗质量评估的前五年启动的分析，并扩大了护理质量评估的范围，以涵盖更广泛定义的概念和质量措施;目标4：制定和验证简单和低成本的病例定义和分类的糖尿病类型的青年，可用于公共监督。 该提案的新奇包括其综合性，汇集了儿童期DM研究的主要和及时的方面：和流行病学研究，在美国独特的，在青年DM发病率的时间趋势;一个病理生理组成部分，解决青年DM的自然史：护理过程和生活质量的研究;和公共卫生的角度对青年DM病例分类。 这项研究对公共卫生至关重要，因为它将提供有关美国不同种族/民族青年中DM是否增加以及增加多少的信息，DM如何影响身体健康，包括并发症，以及有关护理质量和这些青年生活质量的宝贵数据。 俄亥俄州研究中心的主要优势是辛辛那提儿童医院医疗中心（CCHMC）的市场主导地位、CCHMC对研究和糖尿病护理的承诺、CCHMC与周边社区的良好关系以及俄亥俄州研究者成功合作的记录。 基于这些优势，俄亥俄州研究中心使用CCHMC的综合糖尿病患者数据库并建立社区网络，以确定SEARCH 1中俄亥俄州地理区域内99.8%（通过捕获-再捕获分析估计）的青年糖尿病病例。

DESCRIPTION (provided by applicant): This proposal builds upon a five year research project, SEARCH for Diabetes in Youth, its standardized data collection effort, experienced investigator team, established case ascertainment infrastructure, and ethnically diverse population base. This is a common, integrated application from the six SEARCH clinical sites, which proposes to continue and expand the work performed by SEARCH in order to address the following specific research aims: AIM 1: Prospectively ascertain newly diagnosed (2006-2009) incident cases age less than 20 years in order to estimate temporal trends in incidence of DM in youth: AIM 2: Conduct longitudinal follow-up of incident cases already recruited to SEARCH in 2002-2005 in order to document the evolution of newly diagnosed DM according to clinical and biochemical factors; AIM 3; Complete analyses initiated in the first five years of SEARCH and expand the scope of quality of care assessment to encompass more broadly defined concepts and measures of quality; AIM 4: Develop and validate simple and low-cost case definitions and classifications of DM types in youth that can be used for public surveillance. The novelty of this proposal includes its comprehensive nature that brings together major and timely facets of childhood DM research: and epidemiologic study, unique in the United States, of temporal trends in the incidence of DM in youth; a pathophysiologic component addressing the natural history of DM in youth: a study of processes of care and quality of life; and a public health perspective on case classification of DM in youth. This research is critically important to public health as it will provide information about whether and how much DM is increasing among youth of different racial/ ethnic groups in the United States, about how DM impacts on the physical health, including complications, as well as valuable data regarding the quality of care and the quality of life of these youth. The major strengths of the Ohio site are dominant market position of Cincinnati Children's Hospital Medical Center (CCHMC), CCHMC's commitment to research and diabetes care, the excellent rapport CCHMC has with the surrounding community, and the track record of Ohio SEARCH investigators for successful collaboration. Based on these strengths, the Ohio site used a comprehensive diabetes patient database at CCHMC and built a community network to ascertain 99.8% (estimate by capture-recapture analysis) of the cases of diabetes in youth in the Ohio geographic area in SEARCH1.