SEARCH for Diabetes in Youth 2: California Center

描述（由申请人提供）：这项来自加州中心的提案建立在一个为期五年的研究项目，搜索青少年糖尿病，其标准化的数据收集工作，经验丰富的研究者团队，建立的病例确定基础设施和种族多样化的人口基础上。这是来自6个SEARCH临床中心的一项常见的综合应用，它建议继续并扩大SEARCH所做的工作，以解决以下具体研究目标：目标1：前瞻性地确定新诊断（2006-2009）年龄小于20岁的病例，以估计青少年糖尿病发病率的时间趋势；目标2：对2002-2005年已纳入SEARCH的病例进行纵向随访，以便根据临床和生化因素记录新诊断糖尿病的演变；目标3：完成在检索的头五年开展的分析，扩大护理质量评估的范围，以包括更广泛定义的质量概念和措施；目标4：制定和验证可用于公共卫生监测的简单和低成本的青年糖尿病病例定义和分类。该提案的新颖之处在于其综合性，它汇集了儿童糖尿病研究的主要和及时的方面；一项在美国独一无二的流行病学研究，研究青少年糖尿病发病率的时间趋势；一个病理生理组成部分解决在青年糖尿病的自然史；护理学：对护理过程和生活质量的研究；青少年糖尿病病例分类的公共卫生观点。

DESCRIPTION (provided by applicant): This proposal from the California Center builds upon a five year research project, SEARCH for Diabetes in Youth, its standardized data collection effort, experienced investigator team, established case ascertainment infrastructure, and ethnically diverse population base. This is a common, integrated application from the six SEARCH clinical centers, which proposes to continue and expand the work performed by SEARCH in order to address the following specific research aims: AIM 1: Prospectively ascertain newly diagnosed (2006-2009) incident cases age less than 20 years in order to estimate temporal trends in incidence of diabetes mellitus in youth; AIM 2: Conduct longitudinal follow-up of incident cases already recruited to SEARCH in 2002-2005 in order to document the evolution of newly diagnosed diabetes according to clinical and biochemical factors; AIM 3: Complete analyses initiated in the first five years of SEARCH and expand the scope of quality of care assessment to encompass more broadly defined concepts and measures of quality; AIM 4: Develop and validate simple and low-cost case definitions and classifications of diabetes types in youth that can be used for public health surveillance. The novelty of this proposal includes its comprehensive nature that brings together major and timely facets of childhood diabetes research; an epidemiologic study, unique in the United States, of temporal trends in the incidence of diabetes in youth; a pathophysiologic component addressing the natural history of diabetes in youth; a study of processes of care and quality of life; and a public health perspective on case classification of diabetes in youth. The strengths of the California Center are its large, diverse population; that most youth with diabetes receive health care from 1 of the 8 pediatric endocrinologists in the region; and the availability of a vast amount of electronic health data. Of the more than 770,000 youth less than 20 years, over half are Hispanic, African American, or Asian/Pacific Islander, which is representative of southern California. This research is critically important to public health. It will provide information about whether and how much diabetes incidence in the United States in increasing among youth of different backgrounds and how diabetes affects physical health, including complications, as well as data on the quality of care and the quality of life of youth with diabetes.