International Training Program in Environmental Immunoa*

说明.陈述申请的广泛性、重大性和具体目标，以供项目的健康性参考。准确描述研究 避免总结过去的成就和使用第一人称。这一描述是为了作为一个成功的， 从申请书中分离出来时，对所提出的工作的准确描述。如果应用程序运行，此描述将成为公共信息。因此， 不包括机密信息。不要超过所提供的空间。 在人类和环境健康评估方面存在数据缺口，主要原因是缺乏以下能力： 快速、经济地分析大量样品负载。Immunobassays可用于测量 因为它们是快速的、具有成本效益的、敏感的、具体的和适应于 实验室或现场情况。这些测定可用于测量在以下情况下对这些化合物的潜在暴露： 环境样品，如土壤和水，以及食物中。最终，可以进行研究， 以前成本高昂，从而提供了一个更大的数据库，从中作出明智的决定，对人类和 环境卫生。 该项目将提供简单可靠的残留物分析方法和训练有素的大学工作人员， 教育技术人员如何在现场使用这些方法。共和国大学化学系 （乌拉圭），其研究人员有必要的背景，以获得这种方法，并有助于其进一步 发展加州大学戴维斯分校在这方面有一个正在进行的项目，代表了一种理想 培训和技术转让环境，以赞助这一项目。因此，该项目将在以下各部开展： 共和国大学免疫学和生物化学研究所 根据需要，监测环境污染和检测食品中的化学残留物， 全国这些测定是通用的、快速的、灵敏的、特异性的和成本有效的。后一点尤其重要 对于发展中经济体，如乌拉圭和南方共同市场的其他国家， 传统的仪器分析对其广泛使用是一个很大的限制。我们将鼓励区域参与， 南方共同市场的其他国家，南美洲的南部，在这个中心。这些参与者将包括 环境毒理学家，公共卫生专业人员和流行病学家，他们都将发现ELISA的好处 技术为他们的学科。 履约地点（组织、城市、州） 加州大学戴维斯分校 Universidad de la Republicica，乌拉圭 关键人员。见违规行为 姓名： 最后，杰罗德 斯蒂芬？麦柯迪 马克·申克 吊床，布鲁斯 天哪，雪莉 詹姆斯？拉普斯利 Alcalay，Rina 布雷纳 Gonzalez，Gualberto TBA 在第11页。根据需要使用续页，以下列格式提供所需信息。 组织在项目中的角色 加州大学戴维斯分校 加州大学戴维斯分校合作研究者 加州大学戴维斯分校合作研究者 加州大学戴维斯分校合作研究者 加州大学戴维斯分校技术员，SRA IV 加州大学戴维斯分校合作研究者 加州大学戴维斯分校 乌拉圭MFC 乌拉圭MFC 加州大学戴维斯分校和乌拉圭研究生研究 助理 PHS 398（Rev. 4/98）第2 BB页 在整个应用程序的底部连续编号页面。不要使用后缀，如3a，3b。 CC gator/Program Director（最后，第一，中间）： 在打印页和每个续页上键入主要研究者/项目c fr的姓名|<$（有关型号规格，请参阅第6页的说明。） 研究资助

DESCRIPTION. State the application's broad, bng-terlWBijectivesand specifc aims, making reference to tie healthr3SBBness ofthe project. Describe corcisely theresearch design and methods for achieving these goals.Avoid summaries ofpast accomplishments andthe useof first person. This description is meant toserve as asuccinctand accurate description of fie proposed work when separated from theapplicatbn. If theapplication is funcfed, this description, as is, will becomepublic irformation.Therefore, do nothcludeprcprietary/confidentidinformafon. DO NOT EXCEED THE SPACE PROVIDED. Data gaps exist in the assessment of human and environmental health largely due to the lack of ability to analyze large sample loads rapidly and cost effectively. Immunbassays can be used to measure toxic materials in the environment and for human monitoring because they are rapid, cost-effective, sensitive, specific and adaptable to laboratory or field situations. These assays can be used to measure potential exposure to these compounds in environmental samples such as soil and water, and in food. Ultimately, studies can be conducted which were previously cost prohibitive, thus providing a greater database from which to make informed decisions on human and environmental health. This project will provide simple and reliable methods for residue analysis and a trained University staff to educate technicians in how to use these methods in the field. The Faculty of Chemistry, University of the Republic (Uruguay), and its researchers has the necessary background to acquire this methodology and contribute to its further development. The University of California at Davis has an ongoing program in this area and represents an ideal training and technology transfer milieu to sponsor such a project. Thus, the project will build in the Departments of Immunology and Biochemistry of the University of the Republic the capability of developing immunoassays for monitoring environmental contamination and detection of chemical residues in food products according to the needs of the country. These assays are versatile, fast, sensitive, specific, and cost effective. The latter is particularly relevant for developing economies, such as that of Uruguay and other countries of the Mercosur, where the high cost of classical instrumental analysis is a strong limitation to its widespread use. We will encourage regional participation by other countries in the Mercosur, the southern portion of South America, in this Center. Such participants will include environmental toxicologists, public health professionals, and epidemiologists, all of whom will find benefits of ELISA technology for their disciplines. PERFORMANCE SITE(S) (organization, city, state) University of California, Davis, CA Universidad de la Republica, Uruguay KEY PERSONEL. See infractions Name ' ¿ ' Last, Jerold McCurdy, Stephen Schenker, Marc Hammock, Bruce Gee, Shirley Lapsley, James Alcalay, Rina Brena, Breatriz Gonzalez, Gualberto TBA on Page 1 1 . Usecontinuation pages as needed to provide the required information in the format shown below. Organization Role on Project UC Davis P.I. UC Davis Co-Investigator UC Davis Co-Investigator UC Davis Co-Investigator UC Davis Technician, SRA IV UC Davis Co-Investigator UC Davis Consultant Uruguay MFC Uruguay MFC UC Davis & Uruguay Graduate Research Assistants PHS 398 (Rev. 4/98) Page 2 BB Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. cc gator/Program Director (Last, first, middle): Type the name of the principal investigator/program c fr atthetopofeach printed page and each continuation | ¿(For type specifications, see instructions on page 6.) RESEARCH GRANT